DegronMD - Q96M83(CCDC7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V218M	TCGA-2W-A8YY	CESC	TCGA	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.0833
p.V218M	DO223732	CESC	ICGC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.0833
p.V218M	DO50381	ESAD	ICGC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.0833
p.M226I	TCGA-VQ-A8P2	STAD	TCGA	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.L222F	DO229029	LICA	ICGC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1944
p.M221I	DO229036	LICA	ICGC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.H818R	SIDM00458	Acute Myeloid Leukemia	GDSC	DEESGE	DEG_Kelch_Keap1_1	822:827	Mutation rewiring degron network	0.2222
p.H818R	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	822:827	Mutation rewiring degron network	0.2222
p.K733N	SIDM00193	Colorectal Carcinoma	GDSC	PLTTPDKE	DEG_SCF_FBW7_2	742:749	Mutation substituting flanking lysine	0.1944
p.K733N	SNU-81	large intestine	COSMIC	PLTTPDKE	DEG_SCF_FBW7_2	742:749	Mutation substituting flanking lysine	0.1944
p.R231G	SIDM00971	Breast Carcinoma	GDSC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.6457
p.R231G	SIDM00720	Mesothelioma	GDSC	DKENR	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.6457
p.N889S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	ITPGRE	DEG_SCF_FBW7_2	881:886	Mutation rewiring degron network	0.25
p.N889S	KYSE-70	oesophagus	COSMIC	ITPGRE	DEG_SCF_FBW7_2	881:886	Mutation rewiring degron network	0.25
p.D747H	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PLTTPDKE	DEG_SCF_FBW7_2	742:749	Mutation altering degron motif	0.6577
p.D747H	TE-12	oesophagus	COSMIC	PLTTPDKE	DEG_SCF_FBW7_2	742:749	Mutation altering degron motif	0.6577

Kaplan plot for CCDC7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC7

UniProt ID: Q96M83

Entrez ID: 79741

Protein name: Coiled-coil domain-containing protein 7 (Protein BIOT2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC7 in