DegronMD

Uniprot ID: Q96M83

Source protein: Coiled-coil domain-containing protein 7

Source gene: CCDC7

Class: DEG_APCC_KENBOX_2

Location: 227:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7057

ASA_SCORE: 113.12

COIL: 0.6542

CONS_SCORE: 0.5776

DSS_SCORE: 0.4599

HELIX: 0.3306

FCONS_SCORE: 1.1192

RIG_SCORE: 0.6982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V218M	TCGA-2W-A8YY	CESC	TCGA	DKENR	DEG_APCC_KENBOX_2	0.0833
p.V218M	DO223732	CESC	ICGC	DKENR	DEG_APCC_KENBOX_2	0.0833
p.V218M	DO50381	ESAD	ICGC	DKENR	DEG_APCC_KENBOX_2	0.0833
p.M226I	TCGA-VQ-A8P2	STAD	TCGA	DKENR	DEG_APCC_KENBOX_2	0.3056
p.L222F	DO229029	LICA	ICGC	DKENR	DEG_APCC_KENBOX_2	0.1944
p.M221I	DO229036	LICA	ICGC	DKENR	DEG_APCC_KENBOX_2	0.1667
p.R231G	SIDM00971	Breast Carcinoma	GDSC	DKENR	DEG_APCC_KENBOX_2	0.6457
p.R231G	SIDM00720	Mesothelioma	GDSC	DKENR	DEG_APCC_KENBOX_2	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52732	Kinesin-like protein KIF11	DEG_APCC_KENBOX_2	1021:1025	DKENR	APC,CDC20,FZR1	0.9619	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_APCC_KENBOX_2	227:231	DKENR	APC,CDC20,FZR1	0.7057	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_APCC_KENBOX_2	813:817	DKENR	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons