DegronMD

Uniprot ID: P52732

Source protein: Kinesin-like protein KIF11

Source gene: KIF11

Class: DEG_APCC_KENBOX_2

Location: 1021:1025

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9619

ASA_SCORE: 113.72

COIL: 0.6968

CONS_SCORE: 0.263

DSS_SCORE: 0.5857

HELIX: 0.2566

FCONS_SCORE: 1.0042

RIG_SCORE: 0.6628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1012I	TCGA-WE-AAA0	SKCM	TCGA	DKENR	DEG_APCC_KENBOX_2	0.0833
p.F1012I	DO51294	SKCM	ICGC	DKENR	DEG_APCC_KENBOX_2	0.0833

Drug responses associated with KIF11 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E616K (No)	GDSC	ARRY-520	0.8818
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.A282V (No)	GDSC	ARRY-520	0.7256
SIDM00839	COREAD\|large_intestine	p.F534fs*5 (No)	GDSC	ARRY-520	0.0115
SIDM00325	ESCA\|oesophagus	p.I592V (No)	GDSC	S-Trityl-L-cysteine	0.9851
SIDM00325	ESCA\|oesophagus	p.I592V (No)	GDSC	ARRY-520	0.0083
SIDM01045	UCEC\|endometrium	p.A373fs*4 (No)	GDSC	ARRY-520	0.1018
SIDM00145	ALL\|lymphoblastic_leukemia	p.A133V (No)	GDSC	S-Trityl-L-cysteine	1.57
SIDM00145	ALL\|lymphoblastic_leukemia	p.A133V (No)	GDSC	ARRY-520	0.0053
SIDM00311	MESO\|mesothelioma	p.N838H (No)	GDSC	ARRY-520	1.0781
SIDM00781	COREAD\|large_intestine	p.L881fs*2 (No)	GDSC	S-Trityl-L-cysteine	1.5895
SIDM00781	COREAD\|large_intestine	p.L881fs*2 (No)	GDSC	ARRY-520	0.0323
SIDM01107	SKCM\|melanoma	p.N838H (No)	GDSC	S-Trityl-L-cysteine	57.4412
SIDM01107	SKCM\|melanoma	p.N838H (No)	GDSC	ARRY-520	1.1127
SIDM00781	COREAD\|large_intestine	p.Q751R (No)	GDSC	S-Trityl-L-cysteine	1.5895
SIDM00781	COREAD\|large_intestine	p.Q751R (No)	GDSC	ARRY-520	0.0323
SIDM00565	HNSC\|head_and_neck	p.S780L (No)	GDSC	ARRY-520	0.016
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.T437A (No)	GDSC	S-Trityl-L-cysteine	0.9565
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.T437A (No)	GDSC	ARRY-520	0.01
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A373fs*10 (No)	GDSC	ARRY-520	0.0023
SIDM00220	OV\|ovary	p.F772L (No)	GDSC	ARRY-520	0.0048
SIDM00418	THCA\|thyroid	p.S996C (No)	GDSC	ARRY-520	0.0106
SIDM00619	THCA\|thyroid	p.E945K (No)	GDSC	ARRY-520	0.0025
SIDM01045	UCEC\|endometrium	p.S175A (No)	GDSC	ARRY-520	0.1018
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.G96S (No)	GDSC	ARRY-520	0.0619
SIDM00333	UCEC\|endometrium	p.R329K (No)	GDSC	ARRY-520	0.0028
SIDM00783	COREAD\|large_intestine	p.K673fs*3 (No)	GDSC	ARRY-520	0.0024
SIDM00256	NB\|neuroblastoma	p.V794I (No)	GDSC	S-Trityl-L-cysteine	26.1426
SIDM00256	NB\|neuroblastoma	p.V794I (No)	GDSC	ARRY-520	0.0083
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.N456S (No)	GDSC	S-Trityl-L-cysteine	0.9127
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.N456S (No)	GDSC	ARRY-520	0.0023
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.M606V (No)	GDSC	S-Trityl-L-cysteine	0.9127
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.M606V (No)	GDSC	ARRY-520	0.0023
SIDM00102	MESO\|mesothelioma	p.T907S (No)	GDSC	ARRY-520	0.3729
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.L548V (No)	GDSC	S-Trityl-L-cysteine	1.4007
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.L548V (No)	GDSC	ARRY-520	0.0428
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.I647M (No)	GDSC	S-Trityl-L-cysteine	8.273
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.I647M (No)	GDSC	ARRY-520	0.1317
SIDM00683	PRAD\|prostate	p.K673fs*3 (No)	GDSC	S-Trityl-L-cysteine	66.1565
SIDM00683	PRAD\|prostate	p.K673fs*3 (No)	GDSC	ARRY-520	0.0957
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.V627L (No)	GDSC	ARRY-520	1.0129
SIDM00373	UCEC\|endometrium	p.P88Q (No)	GDSC	ARRY-520	0.0025
SIDM01005	LAML\|acute_myeloid_leukaemia	p.S3L (No)	GDSC	S-Trityl-L-cysteine	32.4824
SIDM00291	SKCM\|melanoma	p.T300S (No)	GDSC	ARRY-520	3.1494

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52732	Kinesin-like protein KIF11	DEG_APCC_KENBOX_2	1021:1025	DKENR	APC,CDC20,FZR1	0.9619	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_APCC_KENBOX_2	227:231	DKENR	APC,CDC20,FZR1	0.7057	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_APCC_KENBOX_2	813:817	DKENR	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENR

Degron related mutations and impact score

Drug responses associated with KIF11 mutations

All proteins holding degron of DKENR