DegronMD

Uniprot ID: Q9Y4K1

Source protein: Beta/gamma crystallin domain-containing protein 1

Source gene: CRYBG1

Class: DEG_APCC_KENBOX_2

Location: 813:817

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 113.44

COIL: 0.815

CONS_SCORE: 0.7068

DSS_SCORE: 0.5568

HELIX: 0.1532

FCONS_SCORE: 1.1945

RIG_SCORE: 0.7367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T820S	SIDM00477	Esophageal Carcinoma	GDSC	DKENR	DEG_APCC_KENBOX_2	0.25
p.T820S	OE33	oesophagus	COSMIC	DKENR	DEG_APCC_KENBOX_2	0.25
p.P809L	SIDM00927	Small Cell Lung Carcinoma	GDSC	DKENR	DEG_APCC_KENBOX_2	0.2222
p.P809L	NCI-H510A	lung	COSMIC	DKENR	DEG_APCC_KENBOX_2	0.2222
p.S803I	SIDM00217	Colorectal Carcinoma	GDSC	DKENR	DEG_APCC_KENBOX_2	0.0556
p.S803I	SNU-1040	large_intestine	COSMIC	DKENR	DEG_APCC_KENBOX_2	0.0556
p.L804P	SNU-C5	large_intestine	COSMIC	DKENR	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52732	Kinesin-like protein KIF11	DEG_APCC_KENBOX_2	1021:1025	DKENR	APC,CDC20,FZR1	0.9619	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_APCC_KENBOX_2	227:231	DKENR	APC,CDC20,FZR1	0.7057	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_APCC_KENBOX_2	813:817	DKENR	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons