DegronMD

Uniprot ID: Q96M83

Source protein: Coiled-coil domain-containing protein 7

Source gene: CCDC7

Class: DEG_SCF_FBW7_2

Location: 742:749

E3 ligase: FBXW7

DEGRON score: 0.9458

ASA_SCORE: 104

COIL: 0.9345

CONS_SCORE: 0

DSS_SCORE: 0.7392

HELIX: 0.0291

FCONS_SCORE: 0

RIG_SCORE: 0.656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K733N	SIDM00193	Colorectal Carcinoma	GDSC	PLTTPDKE	DEG_SCF_FBW7_2	0.1944
p.K733N	SNU-81	large_intestine	COSMIC	PLTTPDKE	DEG_SCF_FBW7_2	0.1944
p.D747H	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PLTTPDKE	DEG_SCF_FBW7_2	0.6577
p.D747H	TE-12	oesophagus	COSMIC	PLTTPDKE	DEG_SCF_FBW7_2	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M83	Coiled-coil domain-containing protein 7	DEG_SCF_FBW7_2	742:749	PLTTPDKE	FBXW7	0.9458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons