DegronMD

Uniprot ID: Q96M83

Source protein: Coiled-coil domain-containing protein 7

Source gene: CCDC7

Class: DEG_Kelch_Keap1_1

Location: 822:827

E3 ligase: KEAP1

DEGRON score: 0.804

ASA_SCORE: 104.4167

COIL: 0.8552

CONS_SCORE: 0

DSS_SCORE: 0.8046

HELIX: 0.1228

FCONS_SCORE: 0

RIG_SCORE: 0.5711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H818R	SIDM00458	Acute Myeloid Leukemia	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.2222
p.H818R	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02952	A-kinase anchor protein 12	DEG_Kelch_Keap1_1	541:546	DEESGE	KEAP1	0.9956	More...
Q9P1A6	Disks large-associated protein 2	DEG_Kelch_Keap1_1	443:448	DEESGE	KEAP1	0.6369	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_Kelch_Keap1_1	822:827	DEESGE	KEAP1	0.804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons