DegronMD

Uniprot ID: Q02952

Source protein: A-kinase anchor protein 12

Source gene: AKAP12

Class: DEG_Kelch_Keap1_1

Location: 541:546

E3 ligase: KEAP1

DEGRON score: 0.9956

ASA_SCORE: 107.7

COIL: 0.9223

CONS_SCORE: 0.7432

DSS_SCORE: 0.8517

HELIX: 0.0428

FCONS_SCORE: 1.1238

RIG_SCORE: 0.523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D541Y	TCGA-AX-A05Z	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.7325
p.P551Q	TCGA-EE-A2MD	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.S554Y	TCGA-EO-A3B0	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.5556
p.P555S	TCGA-FD-A43X	BLCA	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.0833
p.Q549E	TCGA-FD-A62O	BLCA	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.25
p.P555L	TCGA-FS-A4FD	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.0833
p.V533D	DO4185	BRCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1111
p.A545D	DO47159	RECA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.7793
p.A543T	DO38192	STAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.7139
p.Q533H	SIDM00534	Colorectal Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.1111
p.Q533H	ACH-000986	Colon/Colorectal Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.1111
p.Q533H	HT-115	large_intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.1111
p.R537I	SIDM01611	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.2222
p.R537I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.2222
p.S554F	SIDM01588	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.5556
p.S554F	ACH-000993	Endometrial/Uterine Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.5556
p.Q549R	ACH-000948	Gastric Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.25
p.Q549R	23132-87	stomach	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.25
p.M552I	HCC2998	large_intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02952	A-kinase anchor protein 12	DEG_Kelch_Keap1_1	541:546	DEESGE	KEAP1	0.9956	More...
Q9P1A6	Disks large-associated protein 2	DEG_Kelch_Keap1_1	443:448	DEESGE	KEAP1	0.6369	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_Kelch_Keap1_1	822:827	DEESGE	KEAP1	0.804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons