DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: DEG_SPOP_SBC_1

Location: 155:159

E3 ligase: SPOP

DEGRON score: 0.9548

ASA_SCORE: 66.94

COIL: 0.8984

CONS_SCORE: 0.5889

DSS_SCORE: 0.3263

HELIX: 0.0298

FCONS_SCORE: 1.0997

RIG_SCORE: 0.7057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E167K	TCGA-21-1079	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1111
p.E167K	DO26846	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1111
p.R150C	TCGA-AP-A0LM	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1944
p.R150C	DO43306	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.K158E	TCGA-DI-A1BU	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.7022
p.K158E	DO42023	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.7022
p.R148Q	TCGA-QC-A7B5	SARC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.R148Q	DO233693	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1389
p.R148Q	DO220239	SARC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1389
p.V156M	DO222765	COCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.7208
p.R150H	DO50451	ESAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.S163L	DO50729	ORCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2222
p.S157P	SIDM02059	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7863
p.G153C	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.2778
p.G153C	LK-2	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	0.2778
p.H169Y	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.0556
p.H169Y	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.0556
p.S168L	SIDM00534	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.0833
p.S168L	HT-115	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.0833
p.H154Y	ACH-000024	Myeloma	CCLE	VSSST	DEG_SPOP_SBC_1	0.3056
p.H154Y	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.3056
p.G152C	LK-2	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	0.25
p.H168Y	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.0833
p.S167L	HT-115	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with DLGAP2 mutations

All proteins holding degron of VSSST