DegronMD

Uniprot ID: O60237

Source protein: Protein phosphatase 1 regulatory subunit 12B

Source gene: PPP1R12B

Class: DEG_SPOP_SBC_1

Location: 574:578

E3 ligase: SPOP

DEGRON score: 0.9726

ASA_SCORE: 83.3

COIL: 0.932

CONS_SCORE: 0.3637

DSS_SCORE: 0.4555

HELIX: 0.0378

FCONS_SCORE: 0.9955

RIG_SCORE: 0.7082

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T566I	TCGA-12-1089	GBM	TCGA	VSSST	DEG_SPOP_SBC_1	0.1111
p.T566I	DO12346	GBM	ICGC	VSSST	DEG_SPOP_SBC_1	0.1111
p.L588F	TCGA-55-7911	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.L588F	TCGA-DS-A0VM	CESC	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.L588F	DO6258	CESC	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.L588F	DO24821	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.R586H	TCGA-AA-3842	COAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1111
p.R586H	TCGA-BR-4184	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1111
p.R586H	DO9394	COAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1111
p.R586H	DO38328	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1111
p.E568D	TCGA-AP-A0LM	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.E568D	DO43306	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.P579Q	TCGA-AP-A1DR	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.P579Q	DO43747	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.D564N	TCGA-BR-8680	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.D564N	DO233884	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.D564N	DO47769	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.S571L	SIDM00392	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.25
p.S571L	SK-MEL-30	skin	COSMIC	VSSST	DEG_SPOP_SBC_1	0.25
p.T566P	SIDM00442	Thyroid Gland Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.1111
p.T566P	ML-1	thyroid	COSMIC	VSSST	DEG_SPOP_SBC_1	0.1111
p.P578S	SIDM00210	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.6752
p.P578S	A2780	ovary	COSMIC	VSSST	DEG_SPOP_SBC_1	0.6752
p.P579T	ACH-000631	Brain Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.3056
p.P579T	KS-1	central_nervous_system	COSMIC	VSSST	DEG_SPOP_SBC_1	0.3056
p.D572Y	ACH-000789	Lung Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.2778
p.D572Y	NCI-H810	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	0.2778
p.D564G	ACH-000994	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.C581Y	ACH-000999	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.25
p.C581Y	SNU-1040	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with PPP1R12B mutations

All proteins holding degron of VSSST