DegronMD - Q5T4S7(UBR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2467L	TCGA-09-2055	OV	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.6471
p.P2467L	DO32676	OV	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.6471
p.Q2846R	TCGA-44-7670	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.3056
p.Q2846R	DO23555	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.3056
p.R1757H	TCGA-59-2349	OV	TCGA	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.2778
p.R1757H	TCGA-A5-A1OF	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.2778
p.R1757H	DO28621	OV	ICGC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.2778
p.R1757H	DO42568	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.2778
p.T2469R	TCGA-61-2104	OV	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7876
p.T2469R	DO31849	OV	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7876
p.E1871Q	TCGA-90-7964	LUSC	TCGA	EMTDQLMVPTL	DEG_COP1_1	1853:1863	Mutation rewiring degron network	0.1111
p.E1871Q	DO27046	LUSC	ICGC	EMTDQLMVPTL	DEG_COP1_1	1853:1863	Mutation rewiring degron network	0.1111
p.S3340L	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1944
p.A2465V	TCGA-AP-A1DK	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.A2465V	DO42033	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.P2927L	TCGA-AX-A3FT	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation rewiring degron network	0.1667
p.D2463N	TCGA-AX-A3FZ	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.D2463N	TCGA-E6-A1LX	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.D2463N	DO41020	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.D2463N	DO41373	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.D2461N	TCGA-BT-A3PH	BLCA	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1944
p.D2461N	DO856	BLCA	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1944
p.I1751T	TCGA-DK-A1A3	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1111
p.I1751T	DO558	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1111
p.S3347F	TCGA-EB-A431	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation altering degron motif	0.9093
p.S3347F	TCGA-FR-A8YC	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation altering degron motif	0.9093
p.G2949E	TCGA-EE-A2MT	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	2939:2943	Mutation rewiring degron network	0.1667
p.A2928T	TCGA-EO-A22U	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation rewiring degron network	0.1944
p.T1771I	TCGA-FI-A2D0	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1111
p.T1771I	DO43891	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1111
p.S3344I	TCGA-IB-7651	PAAD	TCGA	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.3056
p.E2476Q	TCGA-XF-AAMZ	BLCA	TCGA	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.E2476Q	DO219051	BLCA	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.S3346G	DO785	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation altering degron motif	0.6993
p.E2935K	DO1663	BRCA	ICGC	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation altering degron motif	0.7022
p.E2935Q	DO4817	BRCA	ICGC	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation altering degron motif	0.6744
p.G1864E	DO222404	BTCA	ICGC	EMTDQLMVPTL	DEG_COP1_1	1853:1863	Mutation rewiring degron network	0.3056
p.R1757C	DO227709	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.2778
p.S2478F	DO224739	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1111
p.E1853Q	DO233284	GACA	ICGC	EMTDQLMVPTL	DEG_COP1_1	1853:1863	Mutation altering degron motif	0.6744
p.K3351N	DO14192	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.2778
p.A3335D	DO228976	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.0556
p.H2941Q	DO229019	LICA	ICGC	AISTT	DEG_SPOP_SBC_1	2939:2943	Mutation altering degron motif	0.7582
p.P2848H	DO229029	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation altering degron motif	0.6583
p.T2468N	DO229024	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7055
p.H2947N	DO229032	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation rewiring degron network	0.0556
p.H2947N	DO229032	LICA	ICGC	AISTT	DEG_SPOP_SBC_1	2939:2943	Mutation rewiring degron network	0.2222
p.G2837S	DO50970	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.0556
p.G2938R	DO23516	LIRI	ICGC	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation rewiring degron network	0.3056
p.G2938R	DO23516	LIRI	ICGC	AISTT	DEG_SPOP_SBC_1	2939:2943	Mutation rewiring degron network	0.3056
p.S2850C	DO230934	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation altering degron motif	0.7541
p.E3352Q	DO219174	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.25
p.A2852V	DO232761	PBCA	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.3056
p.A2852V	DO38523	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.3056
p.P2842S	DO47263	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.1944
p.A2841S	DO50278	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.1667
p.G2925E	DO38051	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	2933:2937	Mutation rewiring degron network	0.1111
p.D2939N	DO51294	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	2939:2943	Mutation altering degron motif	0.6932
p.A2465T	DO229234	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.E3354G	DO43306	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1944
p.K1769N	SIDM00596	Endometrial Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation blocking ubiquitination signal	0.6111
p.K1769N	ACH-001517	Endometrial/Uterine Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation blocking ubiquitination signal	0.6111
p.K1769N	HEC-1	endometrium	COSMIC	ASTSS	DEG_SPOP_SBC_1	1759:1763	Mutation blocking ubiquitination signal	0.6111
p.A3354G	SIDM00148	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1944
p.A3354G	ACH-000470	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1944
p.A3354G	ACH-002173	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1944
p.A3338T	SIDM00534	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1389
p.A3338T	ACH-000986	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1389
p.A3338T	HT-115	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	3345:3349	Mutation rewiring degron network	0.1389
p.D2854G	SIDM00534	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.25
p.D2854G	ACH-000986	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.25
p.D2854G	HT-115	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.25
p.T2861A	SIDM00161	Biliary Tract Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.0556
p.T2861A	ACH-000141	Gallbladder Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	2847:2851	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBR4

UniProt ID: Q5T4S7

Entrez ID: 23352

Protein name: E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBR4 in