DegronMD

Uniprot ID: Q5T4S7

Source protein: E3 ubiquitin-protein ligase UBR4

Source gene: UBR4

Class: DEG_COP1_1

Location: 1853:1863

E3 ligase: COP1

DEGRON score: 0.8817

ASA_SCORE: 70.1909

COIL: 0.4731

CONS_SCORE: 0.4652

DSS_SCORE: 0.4443

HELIX: 0.0983

FCONS_SCORE: 1.0226

RIG_SCORE: 0.8009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1871Q	TCGA-90-7964	LUSC	TCGA	EMTDQLMVPTL	DEG_COP1_1	0.1111
p.E1871Q	DO27046	LUSC	ICGC	EMTDQLMVPTL	DEG_COP1_1	0.1111
p.G1864E	DO222404	BTCA	ICGC	EMTDQLMVPTL	DEG_COP1_1	0.3056
p.E1853Q	DO233284	GACA	ICGC	EMTDQLMVPTL	DEG_COP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_COP1_1	1853:1863	EMTDQLMVPTL	COP1	0.8817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons