DegronMD

Uniprot ID: Q5T4S7

Source protein: E3 ubiquitin-protein ligase UBR4

Source gene: UBR4

Class: DEG_SPOP_SBC_1

Location: 2939:2943

E3 ligase: SPOP

DEGRON score: 0.9886

ASA_SCORE: 80.9

COIL: 0.8632

CONS_SCORE: 0.3085

DSS_SCORE: 0.7555

HELIX: 0.0396

FCONS_SCORE: 0.9706

RIG_SCORE: 0.6008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2949E	TCGA-EE-A2MT	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.1667
p.H2941Q	DO229019	LICA	ICGC	AISTT	DEG_SPOP_SBC_1	0.7582
p.H2947N	DO229032	LICA	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.G2938R	DO23516	LIRI	ICGC	AISTT	DEG_SPOP_SBC_1	0.3056
p.D2939N	DO51294	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons