DegronMD - Q06413(MEF2C)

GO - Biological processes (BP): apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of AMPA receptor activity [GO:2000311]; regulation of dendritic spine development [GO:0060998]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of NMDA receptor activity [GO:2000310]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q316K	TCGA-78-8640	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6944
p.E141K	TCGA-AG-A002	READ	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2222
p.S307F	TCGA-AJ-A3EL	UCEC	TCGA	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.0556
p.S307F	TCGA-AJ-A3EL	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.D120N	TCGA-AJ-A3EL	UCEC	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.0833
p.D120N	DO41542	UCEC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.0833
p.F142V	TCGA-B5-A1MR	UCEC	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.F142V	DO41758	UCEC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.T284M	TCGA-B5-A3FC	UCEC	TCGA	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1389
p.T284M	TCGA-ED-A66X	LIHC	TCGA	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1389
p.M318I	TCGA-E8-A2EA	THCA	TCGA	AISTT	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7618
p.S123F	TCGA-ER-A19E	SKCM	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.S123F	DO47542	SKCM	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.I138N	TCGA-F4-6856	COAD	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.I138N	DO9114	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.I138N	DO50927	LICA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.I138N	SIDM00572	Gastric Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.I138N	NUGC-3	stomach	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.R130H	TCGA-G4-6315	COAD	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.8244
p.R130H	DO9522	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.8244
p.R130H	DO45187	LIRI	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.8244
p.P137L	DO1749	BRCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6471
p.L133F	DO4879	BRCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6981
p.I124T	DO51649	CESC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.N140S	DO9002	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.25
p.K137E	DO50345	ESAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7022
p.K137Q	DO234196	ESAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6944
p.S124T	DO222739	ESCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.D125N	DO15414	HNSC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2222
p.A291E	DO229022	LICA	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.7701
p.P138H	DO229027	LICA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.S316P	DO50814	LIRI	ICGC	AISTT	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6752
p.Q298K	DO45340	LUAD	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.D125Y	DO26052	LUAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2222
p.I120M	DO26957	LUSC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.0833
p.D122N	DO52686	MALY	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1389
p.V290I	DO33042	PACA	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.E314K	DO38567	STAD	ICGC	AISTT	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7022
p.A288S	DO229208	THCA	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.25
p.M300I	DO38926	THCA	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.25
p.S297F	DO41542	UCEC	ICGC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.7982
p.K136R	SIDM01307	Colorectal Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7237
p.S124F	SIDM01048	Plasma Cell Myeloma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.S124F	EJM	haematopoietic and lymphoid tissue	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.D122E	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1389
p.D122E	KYSE-180	oesophagus	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1389
p.S281N	SIDM00953	Small Cell Lung Carcinoma	GDSC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.0556
p.S281N	CPC-N	lung	COSMIC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.0556
p.M145V	SIDM00351	Oral Cavity Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1111
p.M145V	SAS	upper aerodigestive tract	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1111
p.I124V	SIDM00878	Breast Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.I124V	ACH-000930	Breast Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.I124V	HCC1569	breast	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.P291S	ACH-000152	Brain Cancer	CCLE	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6752
p.I131F	ACH-000703	Lung Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7415
p.I131F	DMS-79	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7415
p.P132S	ACH-000991	Colon/Colorectal Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.P132S	ACH-001550	Skin Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.P132S	ACH-002100	Skin Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.P132S	DJM-1	skin	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.P132S	MCC13	skin	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.P132S	SNU-81	large intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6752
p.T328A	ACH-001735	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.M125V	ACH-002029	Head and Neck Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2222
p.M125V	SAS	upper aerodigestive tract	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2222
p.R130Q	HCC2998	large intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7329
p.L121P	CW-2	large intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1111
p.S284W	JHOS-3	ovary	COSMIC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1389
p.I133V	NCI-H661	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7076
p.S137N	CPC-N	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7069
p.E296K	NCI-H1770	lung	COSMIC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.7022
p.E296K	SNU-81	large intestine	COSMIC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.7022
p.S299T	SNU-C5	large intestine	COSMIC	LATPVVS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.2778

Kaplan plot for MEF2C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEF2C

UniProt ID: Q06413

Entrez ID: 4208

Protein name: Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEF2C in