DegronMD

Uniprot ID: Q06413

Source protein: Myocyte-specific enhancer factor 2C

Source gene: MEF2C

Class: DEG_SCF_FBW7_1

Location: 291:297

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 78.7

COIL: 0.9141

CONS_SCORE: 0.3343

DSS_SCORE: 0.4319

HELIX: 0.0236

FCONS_SCORE: 0.9908

RIG_SCORE: 0.7537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S307F	TCGA-AJ-A3EL	UCEC	TCGA	LATPVVS	DEG_SCF_FBW7_1	0.0556
p.T284M	TCGA-B5-A3FC	UCEC	TCGA	LATPVVS	DEG_SCF_FBW7_1	0.1389
p.T284M	TCGA-ED-A66X	LIHC	TCGA	LATPVVS	DEG_SCF_FBW7_1	0.1389
p.A291E	DO229022	LICA	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.7701
p.Q298K	DO45340	LUAD	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.3056
p.V290I	DO33042	PACA	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.3056
p.A288S	DO229208	THCA	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.25
p.M300I	DO38926	THCA	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.25
p.S297F	DO41542	UCEC	ICGC	LATPVVS	DEG_SCF_FBW7_1	0.7982
p.S281N	SIDM00953	Small Cell Lung Carcinoma	GDSC	LATPVVS	DEG_SCF_FBW7_1	0.0556
p.S281N	CPC-N	lung	COSMIC	LATPVVS	DEG_SCF_FBW7_1	0.0556
p.P291S	ACH-000152	Brain Cancer	CCLE	LATPVVS	DEG_SCF_FBW7_1	0.6752
p.S284W	JHOS-3	ovary	COSMIC	LATPVVS	DEG_SCF_FBW7_1	0.1389
p.E296K	NCI-H1770	lung	COSMIC	LATPVVS	DEG_SCF_FBW7_1	0.7022
p.E296K	SNU-81	large_intestine	COSMIC	LATPVVS	DEG_SCF_FBW7_1	0.7022
p.S299T	SNU-C5	large_intestine	COSMIC	LATPVVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SCF_FBW7_1	291:297	LATPVVS	FBXW7	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons