DegronMD

Uniprot ID: Q06413

Source protein: Myocyte-specific enhancer factor 2C

Source gene: MEF2C

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.8725

ASA_SCORE: 55.64

COIL: 0.859

CONS_SCORE: 0.3006

DSS_SCORE: 0.3169

HELIX: 0.0494

FCONS_SCORE: 0.9702

RIG_SCORE: 0.7643

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M318I	TCGA-E8-A2EA	THCA	TCGA	AISTT	DEG_SPOP_SBC_1	0.7618
p.E314K	DO38567	STAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.7022
p.Q316K	TCGA-78-8640	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.6944
p.S316P	DO50814	LIRI	ICGC	AISTT	DEG_SPOP_SBC_1	0.6752
p.S307F	TCGA-AJ-A3EL	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	0.1389
p.T328A	ACH-001735	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons