DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11306:11310

E3 ligase: SPOP

DEGRON score: 0.8088

ASA_SCORE: 82.16

COIL: 0.8566

CONS_SCORE: 0

DSS_SCORE: 0.5501

HELIX: 0.0148

FCONS_SCORE: 0

RIG_SCORE: 0.7009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T11310S	TCGA-99-8025	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.6005
p.T11310S	DO24255	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.6005
p.G11314S	TCGA-B5-A1MX	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	0.2222
p.G11314S	DO41999	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.P11313L	TCGA-D3-A3ML	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.25
p.P11313L	DO47413	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.25
p.S11312L	TCGA-D3-A5GL	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.2778
p.S11312L	DO47430	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.2778
p.V11296A	TCGA-E6-A1M0	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	0.0556
p.V11296A	DO43682	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.0556
p.S11308L	TCGA-EE-A29M	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.7667
p.S11308L	DO37404	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.7667
p.A11306V	TCGA-RP-A695	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.5825
p.A11306V	DO51270	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.5825
p.P11299L	DO220886	MELA	ICGC	AISTT	DEG_SPOP_SBC_1	0.1389
p.P11299L	SIDM00336	Melanoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.1389
p.P11299L	ACH-000881	Skin Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.1389
p.P11299L	MEL-JUSO	skin	COSMIC	AISTT	DEG_SPOP_SBC_1	0.1389
p.P11316L	DO27943	ORCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.1667
p.P11316A	DO50305	PAEN	ICGC	AISTT	DEG_SPOP_SBC_1	0.1667
p.E11300G	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.1667
p.E11300G	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.1667
p.E11300G	SIDM00701	Non-Cancerous	GDSC	AISTT	DEG_SPOP_SBC_1	0.1667
p.T11310N	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.7055
p.T11310N	ACH-000669	Lung Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.7055
p.T11310N	SW900	lung	COSMIC	AISTT	DEG_SPOP_SBC_1	0.7055
p.G11317V	SIDM01608	Endometrial Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.1389
p.G11317V	ACH-000990	Endometrial/Uterine Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AISTT