DegronMD

Uniprot ID: Q9NP73

Source protein: Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

Source gene: ALG13

Class: DEG_SPOP_SBC_1

Location: 873:877

E3 ligase: SPOP

DEGRON score: 0.9865

ASA_SCORE: 72.6

COIL: 0.8282

CONS_SCORE: 0.3432

DSS_SCORE: 0.369

HELIX: 0.0312

FCONS_SCORE: 0.9875

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T877A	TCGA-44-6144	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.7139
p.T877A	DO24190	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.7139
p.S880Y	TCGA-68-7755	LUSC	TCGA	AISTT	DEG_SPOP_SBC_1	0.25
p.S880Y	DO26512	LUSC	ICGC	AISTT	DEG_SPOP_SBC_1	0.25
p.S875C	TCGA-69-7974	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.7541
p.S875C	DO23850	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.7541
p.A869V	TCGA-C5-A1MJ	CESC	TCGA	AISTT	DEG_SPOP_SBC_1	0.2222
p.A869V	DO49017	CESC	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.T876I	TCGA-DF-A2KN	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	0.7078
p.T876I	DO223282	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.7078
p.A869T	TCGA-EI-6882	READ	TCGA	AISTT	DEG_SPOP_SBC_1	0.2222
p.A869T	DO36531	READ	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.G867C	SIDM02050	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.1667
p.A873P	SIDM00541	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.6392
p.A873P	SIDM00317	Kidney Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.6392
p.I885M	ACH-001568	Skin Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.1111
p.P870L	HCC2998	large_intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	0.25
p.T874S	CW-2	large_intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons