DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_SPOP_SBC_1

Location: 1185:1189

E3 ligase: SPOP

DEGRON score: 0.6094

ASA_SCORE: 44.98

COIL: 0.3962

CONS_SCORE: 0.3834

DSS_SCORE: 0.3274

HELIX: 0.0114

FCONS_SCORE: 0.9516

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1192D	TCGA-29-A5NZ	OV	TCGA	AISTT	DEG_SPOP_SBC_1	0.25
p.E1175Q	TCGA-XF-A9SM	BLCA	TCGA	AISTT	DEG_SPOP_SBC_1	0.0556
p.A1193V	DO8119	COAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.R1188W	DO227549	COCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.8634
p.R1188Q	DO219533	LIHC	ICGC	AISTT	DEG_SPOP_SBC_1	0.7329
p.S1182Y	DO229177	LMS	ICGC	AISTT	DEG_SPOP_SBC_1	0.25
p.R1188L	DO37715	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.8428
p.P1180L	DO42023	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.6389
p.P1180S	DO41235	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.6389
p.V1194A	DO41331	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	0.1944
p.P1190S	SIDM00608	Plasma Cell Myeloma	GDSC	AISTT	DEG_SPOP_SBC_1	0.3056
p.P1190S	SIDM00527	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.3056
p.P1190S	ACH-000714	Myeloma	CCLE	AISTT	DEG_SPOP_SBC_1	0.3056
p.P1190S	ACH-000935	Colon/Colorectal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.3056
p.P1190S	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	0.3056
p.P1190S	MDST8	large_intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	0.3056
p.K1197E	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.5556
p.K1197E	ACH-000855	Esophageal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.5556
p.K1197E	KYSE-150	oesophagus	COSMIC	AISTT	DEG_SPOP_SBC_1	0.5556
p.N1193S	SIDM00980	Gastric Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.2222
p.N1193S	ACH-000948	Gastric Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.2222
p.N1193S	23132-87	stomach	COSMIC	AISTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons