DegronMD - Q9H6B1(ZNF385D)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T146K	TCGA-17-Z028	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.S167N	TCGA-44-8119	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.S167N	DO24399	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.P153Q	TCGA-49-4505	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.3056
p.P153Q	DO25498	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.3056
p.T149N	TCGA-50-6590	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.T149N	DO24692	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.T149S	TCGA-69-8255	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.T149S	DO25360	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.V168I	TCGA-AA-3715	COAD	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.V168I	DO8018	COAD	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.S166C	TCGA-AG-A002	READ	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.G151W	TCGA-CN-5360	HNSC	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.G151W	DO14662	HNSC	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.V168F	TCGA-D6-A74Q	HNSC	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.V168F	DO52087	HNSC	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.T160A	TCGA-DJ-A2Q0	THCA	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.T160A	DO39659	THCA	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.D147Y	TCGA-EE-A20F	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1389
p.V168G	TCGA-EE-A2GS	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.V168G	DO37465	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.R164H	TCGA-F5-6464	READ	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1667
p.R164H	DO36566	READ	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1667
p.G151R	TCGA-FD-A62N	BLCA	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.G151R	DO44081	BLCA	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.D147N	TCGA-FR-A726	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1389
p.S167G	DO217864	BTCA	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.E162D	DO220886	MELA	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222
p.T146A	DO229268	THCA	ICGC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.I155M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6507
p.I155M	ACH-002256	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6507
p.I155M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6507
p.T158M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	SIDM00677	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	SIDM00153	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	ACH-000007	Colon/Colorectal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	ACH-000964	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	ACH-001127	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423
p.T158M	LS-513	large intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF385D

UniProt ID: Q9H6B1

Entrez ID: 79750

Protein name: Zinc finger protein 385D (Zinc finger protein 659)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF385D in