DegronMD

Uniprot ID: Q9H6B1

Source protein: Zinc finger protein 385D

Source gene: ZNF385D

Class: DEG_SPOP_SBC_1

Location: 154:158

E3 ligase: SPOP

DEGRON score: 0.9854

ASA_SCORE: 69.7

COIL: 0.7988

CONS_SCORE: 0.5144

DSS_SCORE: 0.5149

HELIX: 0.0698

FCONS_SCORE: 0.9311

RIG_SCORE: 0.7526

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T146K	TCGA-17-Z028	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.1111
p.S167N	TCGA-44-8119	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.0833
p.S167N	DO24399	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.0833
p.P153Q	TCGA-49-4505	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.3056
p.P153Q	DO25498	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.3056
p.T149N	TCGA-50-6590	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.1944
p.T149N	DO24692	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.1944
p.T149S	TCGA-69-8255	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.1944
p.T149S	DO25360	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.1944
p.V168I	TCGA-AA-3715	COAD	TCGA	AISTT	DEG_SPOP_SBC_1	0.0556
p.V168I	DO8018	COAD	ICGC	AISTT	DEG_SPOP_SBC_1	0.0556
p.S166C	TCGA-AG-A002	READ	TCGA	AISTT	DEG_SPOP_SBC_1	0.1111
p.G151W	TCGA-CN-5360	HNSC	TCGA	AISTT	DEG_SPOP_SBC_1	0.25
p.G151W	DO14662	HNSC	ICGC	AISTT	DEG_SPOP_SBC_1	0.25
p.V168F	TCGA-D6-A74Q	HNSC	TCGA	AISTT	DEG_SPOP_SBC_1	0.0556
p.V168F	DO52087	HNSC	ICGC	AISTT	DEG_SPOP_SBC_1	0.0556
p.T160A	TCGA-DJ-A2Q0	THCA	TCGA	AISTT	DEG_SPOP_SBC_1	0.2778
p.T160A	DO39659	THCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.2778
p.D147Y	TCGA-EE-A20F	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.1389
p.V168G	TCGA-EE-A2GS	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.0556
p.V168G	DO37465	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	0.0556
p.R164H	TCGA-F5-6464	READ	TCGA	AISTT	DEG_SPOP_SBC_1	0.1667
p.R164H	DO36566	READ	ICGC	AISTT	DEG_SPOP_SBC_1	0.1667
p.G151R	TCGA-FD-A62N	BLCA	TCGA	AISTT	DEG_SPOP_SBC_1	0.25
p.G151R	DO44081	BLCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.25
p.D147N	TCGA-FR-A726	SKCM	TCGA	AISTT	DEG_SPOP_SBC_1	0.1389
p.S167G	DO217864	BTCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.0833
p.E162D	DO220886	MELA	ICGC	AISTT	DEG_SPOP_SBC_1	0.2222
p.T146A	DO229268	THCA	ICGC	AISTT	DEG_SPOP_SBC_1	0.1111
p.I155M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	0.6507
p.I155M	ACH-002256	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	0.6507
p.I155M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	0.6507
p.T158M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	SIDM00677	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	SIDM00153	T-Lymphoblastic Leukemia	GDSC	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	ACH-000007	Colon/Colorectal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	ACH-000964	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	ACH-001127	Leukemia	CCLE	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	0.7423
p.T158M	LS-513	large_intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_SPOP_SBC_1	314:318	AISTT	SPOP	0.8725	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2939:2943	AISTT	SPOP	0.9886	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1185:1189	AISTT	SPOP	0.6094	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11306:11310	AISTT	SPOP	0.8088	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	873:877	AISTT	SPOP	0.9865	More...
Q9H6B1	Zinc finger protein 385D	DEG_SPOP_SBC_1	154:158	AISTT	SPOP	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISTT

Degron related mutations and impact score

Drug responses associated with ZNF385D mutations

All proteins holding degron of AISTT