DegronMD - Q9NP73(ALG13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C968Y	TCGA-05-4249	LUAD	TCGA	PPPY	ITCH	963:966	Mutation rewiring degron network	0.2778
p.C968Y	DO23891	LUAD	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.2778
p.D969H	TCGA-17-Z033	LUAD	TCGA	PPPY	ITCH	963:966	Mutation rewiring degron network	0.25
p.T877A	TCGA-44-6144	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7139
p.T877A	DO24190	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7139
p.D1056N	TCGA-49-AARE	LUAD	TCGA	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.5821
p.D1056N	DO218922	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.5821
p.S1057Y	TCGA-60-2710	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.712
p.S1057Y	DO26938	LUSC	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.712
p.S880Y	TCGA-68-7755	LUSC	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.25
p.S880Y	DO26512	LUSC	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.25
p.S875C	TCGA-69-7974	LUAD	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7541
p.S875C	DO23850	LUAD	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7541
p.G972S	TCGA-A6-3809	COAD	TCGA	PPPY	ITCH	963:966	Mutation rewiring degron network	0.1667
p.G972S	DO8722	COAD	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.1667
p.V1013A	TCGA-AP-A051	UCEC	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.2778
p.V1013A	DO42673	UCEC	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.2778
p.Y1016D	TCGA-AX-A0J0	UCEC	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation altering degron motif	0.6214
p.Y1016D	DO41133	UCEC	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation altering degron motif	0.6214
p.P962S	TCGA-B5-A3FC	UCEC	TCGA	PPPY	ITCH	963:966	Mutation rewiring degron network	0.3056
p.P962S	DO41871	UCEC	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.3056
p.A869V	TCGA-C5-A1MJ	CESC	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.A869V	DO49017	CESC	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.P1053L	TCGA-D1-A167	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.P1053L	DO40978	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.P1053L	SIDM00118	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.P1053L	ACH-001081	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.P1053L	HCC2998	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.T876I	TCGA-DF-A2KN	UCEC	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7078
p.T876I	DO223282	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7078
p.P1030H	TCGA-DJ-A2QB	THCA	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.1389
p.P1030H	DO39421	THCA	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.1389
p.A869T	TCGA-EI-6882	READ	TCGA	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.A869T	DO36531	READ	ICGC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.R799C	TCGA-EO-A22U	UCEC	TCGA	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0556
p.R799C	DO222731	MELA	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0556
p.R799C	DO43755	UCEC	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0556
p.E1014D	TCGA-EO-A3B0	UCEC	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.3056
p.E1014D	DO229026	LICA	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.3056
p.E1014D	DO219773	UCEC	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.3056
p.Q822H	TCGA-ER-A19P	SKCM	TCGA	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.Q822H	DO47623	SKCM	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.P970S	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	963:966	Mutation rewiring degron network	0.2222
p.P970S	DO37406	SKCM	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.2222
p.H1012R	TCGA-HU-A4GQ	STAD	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.25
p.H1012R	DO47767	STAD	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.25
p.S1058L	TCGA-QC-A7B5	SARC	TCGA	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.7667
p.S1058L	DO220239	SARC	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.7667
p.P1017S	TCGA-ZF-AA4T	BLCA	TCGA	NYPVYTEPP	CBL_PTK	1015:1023	Mutation altering degron motif	0.5641
p.P1017S	DO219084	BLCA	ICGC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation altering degron motif	0.5641
p.H1062Y	DO233806	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.25
p.V1069L	DO228952	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.D974Y	DO229015	LICA	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.1111
p.A814S	DO229024	LICA	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.3056
p.A800S	DO229026	LICA	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.L961P	DO229056	LICA	ICGC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.2778
p.S807L	DO45049	LINC	ICGC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.2778
p.G867C	SIDM02050	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.A873P	SIDM00541	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.6392
p.A873P	SIDM00317	Kidney Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.6392
p.Q822K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.Q822K	ACH-000873	Esophageal Cancer	CCLE	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.Q822K	KYSE-270	oesophagus	COSMIC	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.0833
p.Q1027K	SIDM01387	Small Cell Lung Carcinoma	GDSC	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.2222
p.Q1027K	ACH-000921	Lung Cancer	CCLE	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.2222
p.T1028I	ACH-000954	Endometrial/Uterine Cancer	CCLE	NYPVYTEPP	CBL_PTK	1015:1023	Mutation rewiring degron network	0.1944
p.A817E	ACH-001211	Rhabdoid	CCLE	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation rewiring degron network	0.2222
p.I885M	ACH-001568	Skin Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1111
p.Y810D	ACH-001977	Primary	CCLE	VYSTT	DEG_SPOP_SBC_1	809:813	Mutation altering degron motif	0.6214
p.P870L	HCC2998	large intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.25
p.T874S	CW-2	large intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7116
p.P975L	HCC2998	large intestine	COSMIC	PPPY	ITCH	963:966	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALG13

UniProt ID: Q9NP73

Entrez ID: 79868

Protein name: Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC 2.4.1.141) (EC 3.4.19.12) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) (UDP-N-acetylglucosamine transferase subunit ALG13 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALG13 in