DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
NYPVYTEPP
Uniprot ID:
Q9NP73
Source protein:
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
Source gene:
ALG13
Class:
CBL_PTK
Location:
1015:1023
E3 ligase:
CBL
DEGRON score:
0.9342
ASA_SCORE:
85.7778
COIL:
0.9337
CONS_SCORE:
0.3737
DSS_SCORE:
0.3212
HELIX:
0.0138
FCONS_SCORE:
0.9773
RIG_SCORE:
0.7931
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V1013A
TCGA-AP-A051
UCEC
TCGA
NYPVYTEPP
CBL_PTK
0.2778
p.V1013A
DO42673
UCEC
ICGC
NYPVYTEPP
CBL_PTK
0.2778
p.Y1016D
TCGA-AX-A0J0
UCEC
TCGA
NYPVYTEPP
CBL_PTK
0.6214
p.Y1016D
DO41133
UCEC
ICGC
NYPVYTEPP
CBL_PTK
0.6214
p.P1030H
TCGA-DJ-A2QB
THCA
TCGA
NYPVYTEPP
CBL_PTK
0.1389
p.P1030H
DO39421
THCA
ICGC
NYPVYTEPP
CBL_PTK
0.1389
p.E1014D
TCGA-EO-A3B0
UCEC
TCGA
NYPVYTEPP
CBL_PTK
0.3056
p.E1014D
DO229026
LICA
ICGC
NYPVYTEPP
CBL_PTK
0.3056
p.E1014D
DO219773
UCEC
ICGC
NYPVYTEPP
CBL_PTK
0.3056
p.H1012R
TCGA-HU-A4GQ
STAD
TCGA
NYPVYTEPP
CBL_PTK
0.25
p.H1012R
DO47767
STAD
ICGC
NYPVYTEPP
CBL_PTK
0.25
p.P1017S
TCGA-ZF-AA4T
BLCA
TCGA
NYPVYTEPP
CBL_PTK
0.5641
p.P1017S
DO219084
BLCA
ICGC
NYPVYTEPP
CBL_PTK
0.5641
p.Q1027K
SIDM01387
Small Cell Lung Carcinoma
GDSC
NYPVYTEPP
CBL_PTK
0.2222
p.Q1027K
ACH-000921
Lung Cancer
CCLE
NYPVYTEPP
CBL_PTK
0.2222
p.T1028I
ACH-000954
Endometrial/Uterine Cancer
CCLE
NYPVYTEPP
CBL_PTK
0.1944
Drug responses associated with ALG13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NYPVYTEPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NP73
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
CBL_PTK
1015:1023
NYPVYTEPP
CBL
0.9342
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