DegronMD

Uniprot ID: Q9NP73

Source protein: Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

Source gene: ALG13

Class: DEG_SPOP_SBC_1

Location: 809:813

E3 ligase: SPOP

DEGRON score: 0.5195

ASA_SCORE: 86.12

COIL: 0.8544

CONS_SCORE: 0.3927

DSS_SCORE: 0.4683

HELIX: 0.06

FCONS_SCORE: 1.0006

RIG_SCORE: 0.7452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R799C	TCGA-EO-A22U	UCEC	TCGA	VYSTT	DEG_SPOP_SBC_1	0.0556
p.R799C	DO222731	MELA	ICGC	VYSTT	DEG_SPOP_SBC_1	0.0556
p.R799C	DO43755	UCEC	ICGC	VYSTT	DEG_SPOP_SBC_1	0.0556
p.Q822H	TCGA-ER-A19P	SKCM	TCGA	VYSTT	DEG_SPOP_SBC_1	0.0833
p.Q822H	DO47623	SKCM	ICGC	VYSTT	DEG_SPOP_SBC_1	0.0833
p.A814S	DO229024	LICA	ICGC	VYSTT	DEG_SPOP_SBC_1	0.3056
p.A800S	DO229026	LICA	ICGC	VYSTT	DEG_SPOP_SBC_1	0.0833
p.S807L	DO45049	LINC	ICGC	VYSTT	DEG_SPOP_SBC_1	0.2778
p.Q822K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	VYSTT	DEG_SPOP_SBC_1	0.0833
p.Q822K	ACH-000873	Esophageal Cancer	CCLE	VYSTT	DEG_SPOP_SBC_1	0.0833
p.Q822K	KYSE-270	oesophagus	COSMIC	VYSTT	DEG_SPOP_SBC_1	0.0833
p.A817E	ACH-001211	Rhabdoid	CCLE	VYSTT	DEG_SPOP_SBC_1	0.2222
p.Y810D	ACH-001977	Primary	CCLE	VYSTT	DEG_SPOP_SBC_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	809:813	VYSTT	SPOP	0.5195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons