DegronMD

Uniprot ID: Q06413

Source protein: Myocyte-specific enhancer factor 2C

Source gene: MEF2C

Class: DEG_APCC_DBOX_1

Location: 129:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.801

ASA_SCORE: 86.2222

COIL: 0.7053

CONS_SCORE: 0.334

DSS_SCORE: 0.3683

HELIX: 0.2287

FCONS_SCORE: 1.0314

RIG_SCORE: 0.7953

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E141K	TCGA-AG-A002	READ	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.2222
p.D120N	TCGA-AJ-A3EL	UCEC	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.0833
p.D120N	DO41542	UCEC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.0833
p.F142V	TCGA-B5-A1MR	UCEC	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.F142V	DO41758	UCEC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.S123F	TCGA-ER-A19E	SKCM	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.1667
p.S123F	DO47542	SKCM	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1667
p.I138N	TCGA-F4-6856	COAD	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.I138N	DO9114	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.I138N	DO50927	LICA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.I138N	SIDM00572	Gastric Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.I138N	NUGC-3	stomach	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.R130H	TCGA-G4-6315	COAD	TCGA	SRQRLCAVP	DEG_APCC_DBOX_1	0.8244
p.R130H	DO9522	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.8244
p.R130H	DO45187	LIRI	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.8244
p.P137L	DO1749	BRCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6471
p.L133F	DO4879	BRCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6981
p.I124T	DO51649	CESC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.N140S	DO9002	COAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.25
p.K137E	DO50345	ESAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7022
p.K137Q	DO234196	ESAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6944
p.S124T	DO222739	ESCA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.D125N	DO15414	HNSC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.2222
p.P138H	DO229027	LICA	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.3056
p.D125Y	DO26052	LUAD	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.2222
p.I120M	DO26957	LUSC	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.0833
p.D122N	DO52686	MALY	ICGC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1389
p.K136R	SIDM01307	Colorectal Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7237
p.S124F	SIDM01048	Plasma Cell Myeloma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.S124F	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.D122E	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1389
p.D122E	KYSE-180	oesophagus	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1389
p.M145V	SIDM00351	Oral Cavity Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1111
p.M145V	SAS	upper_aerodigestive_tract	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1111
p.I124V	SIDM00878	Breast Carcinoma	GDSC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.I124V	ACH-000930	Breast Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.I124V	HCC1569	breast	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1944
p.I131F	ACH-000703	Lung Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.7415
p.I131F	DMS-79	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7415
p.P132S	ACH-000991	Colon/Colorectal Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.P132S	ACH-001550	Skin Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.P132S	ACH-002100	Skin Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.P132S	DJM-1	skin	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.P132S	MCC13	skin	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.P132S	SNU-81	large_intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.6752
p.M125V	ACH-002029	Head and Neck Cancer	CCLE	SRQRLCAVP	DEG_APCC_DBOX_1	0.2222
p.M125V	SAS	upper_aerodigestive_tract	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.2222
p.R130Q	HCC2998	large_intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7329
p.L121P	CW-2	large_intestine	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.1111
p.I133V	NCI-H661	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7076
p.S137N	CPC-N	lung	COSMIC	SRQRLCAVP	DEG_APCC_DBOX_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRQRLCAVP

Degron related mutations and impact score

Drug responses associated with MEF2C mutations

All proteins holding degron of SRQRLCAVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06413	Myocyte-specific enhancer factor 2C	DEG_APCC_DBOX_1	129:137	SRQRLCAVP	APC,CDC20,FZR1	0.801	More...