DegronMD

Uniprot ID: Q12951

Source protein: Forkhead box protein I1

Source gene: FOXI1

Class: DEG_SPOP_SBC_1

Location: 222:226

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 85.22

COIL: 0.6744

CONS_SCORE: 0.6377

DSS_SCORE: 0.5232

HELIX: 0.3184

FCONS_SCORE: 1.0823

RIG_SCORE: 0.6319

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T223S	HCT-116	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.7116
p.T226I	SIDM01080	Oral Cavity Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM01716	Non-Cancerous	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM00175	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM00892	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM00542	Glioblastoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.T226I	SIDM01700	Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7078
p.A227T	TCGA-BG-A222	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.A227T	DO42977	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.A227S	DO228948	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.D221H	SIDM00566	Oral Cavity Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.3056
p.D221H	ACH-001625	Head and Neck Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.3056
p.D221H	OSC-19	upper_aerodigestive_tract	COSMIC	VSSST	DEG_SPOP_SBC_1	0.3056
p.R216G	TCGA-05-4382	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.R216G	DO24900	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.R216G	SIDM01608	Endometrial Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.1667
p.R216G	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.1667
p.R216S	TCGA-44-2657	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.R216S	DO25020	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.R213C	TCGA-28-2509	GBM	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833
p.R213C	TCGA-B5-A1MR	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833
p.R213C	TCGA-EB-A85J	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 25 of 32 entries

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Drug responses associated with FOXI1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...

Showing 1 to 19 of 19 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with FOXI1 mutations

All proteins holding degron of VSSST