DegronMD

Uniprot ID: O75496

Source protein: Geminin

Source gene: GMNN

Class: DEG_SPOP_SBC_1

Location: 199:203

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 79.78

COIL: 0.7766

CONS_SCORE: 0.5784

DSS_SCORE: 0.5257

HELIX: 0.092

FCONS_SCORE: 1.0049

RIG_SCORE: 0.6895

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S202F	TCGA-21-1070	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.9093
p.S202F	DO27088	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.9093
p.V199A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.5825
p.V199A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.5825
p.V199A	ACH-000964	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.5825
p.V199A	ACH-001127	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.5825
p.V199A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.5825
p.G197V	DO229035	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2778
p.A195T	DO228938	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2222
p.P207L	DO220899	MELA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2222
p.C194G	DO233780	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.T193M	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.T193M	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.E190D	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833
p.E190D	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 15 of 15 entries

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Drug responses associated with GMNN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...

Showing 1 to 19 of 19 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with GMNN mutations

All proteins holding degron of VSSST