DegronMD - Q2LD37(KIAA1109)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R3519Q	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	3517:3519	Mutation altering degron motif	0.7329
p.R3519Q	DO10880	GBM	ICGC	DYR	CBL_MET	3517:3519	Mutation altering degron motif	0.7329
p.R3616Q	TCGA-25-1329	OV	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.1111
p.R3616Q	DO31230	OV	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.1111
p.V2692L	TCGA-33-6738	LUSC	TCGA	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1389
p.V2692L	DO26516	LUSC	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1389
p.E3642K	TCGA-46-3765	LUSC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.0556
p.E3642K	DO26959	LUSC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.0556
p.E1542K	TCGA-4Z-AA7W	BLCA	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation altering degron motif	0.7022
p.E1542K	DO218984	BLCA	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation altering degron motif	0.7022
p.D4019H	TCGA-90-7767	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.0556
p.D4019H	DO26692	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.0556
p.P2968S	TCGA-99-8025	LUAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.1389
p.P2968S	DO24255	LUAD	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.1389
p.G2672C	TCGA-A5-A0G2	UCEC	TCGA	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1111
p.G2672C	DO41235	UCEC	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1111
p.V3449I	TCGA-A5-A0VP	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.1111
p.V3449I	DO42600	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.1111
p.T3432I	TCGA-A8-A08L	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.1944
p.T3432I	DO3110	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.1944
p.R710H	TCGA-AA-3510	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.R710H	DO7783	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.S1526C	TCGA-AG-A01J	READ	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.0556
p.S1526C	DO36385	READ	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.0556
p.A3622D	TCGA-AJ-A3EK	UCEC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.2778
p.A3622D	DO41584	UCEC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.2778
p.S4037Y	TCGA-AP-A1DV	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.2222
p.S4037Y	DO43186	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.2222
p.V2959D	TCGA-AR-A24S	BRCA	TCGA	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.6674
p.V2959D	DO1414	BRCA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.6674
p.T2536I	TCGA-AX-A06F	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.3056
p.T2536I	DO41752	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.3056
p.R710C	TCGA-AX-A1CE	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.R710C	DO42280	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.S2947Y	TCGA-B5-A1MR	UCEC	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.712
p.S2947Y	DO41758	UCEC	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.712
p.A2538T	TCGA-B5-A3FA	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.25
p.A2538T	DO52402	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.25
p.S2537G	TCGA-BG-A0LX	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.2778
p.S2537G	DO41919	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.2778
p.T2943A	TCGA-BR-4361	STAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.7139
p.T2943A	DO38887	STAD	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.7139
p.S2315N	TCGA-BR-6452	STAD	TCGA	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation altering degron motif	0.7069
p.S2315N	DO38404	STAD	ICGC	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation altering degron motif	0.7069
p.T2950N	TCGA-BR-8382	STAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950N	TCGA-BR-8382	STAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.T2950N	TCGA-DM-A1HB	COAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950N	TCGA-DM-A1HB	COAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.T2950N	DO47925	STAD	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950N	DO47925	STAD	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.R3625K	TCGA-CN-4723	HNSC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation altering degron motif	0.7237
p.R3625K	DO14830	HNSC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation altering degron motif	0.7237
p.R1532C	TCGA-CR-6481	HNSC	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532C	TCGA-D3-A51T	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532C	TCGA-EE-A3AG	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532C	DO14990	HNSC	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532C	DO37471	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532C	DO47389	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.S1529L	TCGA-D3-A8GI	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.1389
p.S1529L	DO50284	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.1389
p.V2529M	TCGA-DB-5279	LGG	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	SIDM00266	Ewing's Sarcoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	SIDM00056	Thyroid Gland Carcinoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	SIDM01316	Ewing's Sarcoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	ES1	bone	COSMIC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.V2529M	K5	thyroid	COSMIC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation altering degron motif	0.6097
p.R3630Q	TCGA-DM-A1HB	COAD	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation altering degron motif	0.6218
p.R3630Q	DO227844	COCA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation altering degron motif	0.6218
p.S3619N	TCGA-EA-A3HS	CESC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation blocking phosphorylation signal	0.6389
p.S3619N	DO6260	CESC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation blocking phosphorylation signal	0.6389
p.S2947F	TCGA-EB-A44O	SKCM	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.7982
p.S2947F	DO47272	SKCM	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.7982
p.S2693L	TCGA-EE-A182	SKCM	TCGA	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1111
p.S2693L	DO37814	SKCM	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.1111
p.Q2966K	TCGA-EE-A20C	SKCM	TCGA	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.1944
p.Q2966K	DO222775	MELA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.1944
p.Q2966K	DO47665	SKCM	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.1944
p.S2323Y	TCGA-EE-A2MF	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	2319:2323	Mutation altering degron motif	0.712
p.S2323Y	DO222491	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	2319:2323	Mutation altering degron motif	0.712
p.S2323Y	DO51249	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	2319:2323	Mutation altering degron motif	0.712
p.S2528F	TCGA-EE-A3AB	SKCM	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.3056
p.S2528F	DO222670	MELA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.3056
p.S2528F	DO38057	SKCM	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.3056
p.G3529R	TCGA-ER-A193	SKCM	TCGA	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.0556
p.G3529R	DO233179	GACA	ICGC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.0556
p.G3529R	DO47368	SKCM	ICGC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.0556
p.S2537N	TCGA-FI-A2D0	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.2778
p.S2537N	DO43891	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.2778
p.R1532H	TCGA-FR-A728	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.R1532H	DO48550	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2222
p.P4020H	TCGA-IB-7651	PAAD	TCGA	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.0833
p.P4020H	DO46657	PAAD	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.0833
p.G3433A	TCGA-J2-A4AD	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.2222
p.G3433A	DO23915	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.2222
p.M4021V	TCGA-LN-A4A1	ESCA	TCGA	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.1111
p.S1552Y	TCGA-VQ-A8P2	STAD	TCGA	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.0556
p.S1552Y	DO51761	STAD	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.0556
p.P2934T	TCGA-XF-A9SZ	BLCA	TCGA	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.1389
p.P2934T	DO51919	BLCA	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.1389
p.S3621C	TCGA-XF-A9T5	BLCA	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.25
p.S3621C	DO51925	BLCA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.25
p.M2680I	DO48442	BLCA	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation altering degron motif	0.6507
p.M2680I	DO229026	LICA	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation altering degron motif	0.6507
p.V701L	DO1123	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2222
p.G2970D	DO1118	BRCA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.0833
p.R2670S	DO50392	ESAD	ICGC	MTIHMD	LIG_APCC_ABBA_1	2680:2685	Mutation rewiring degron network	0.0556
p.M3631L	DO228740	GACA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation altering degron motif	0.5999
p.S4030L	DO233168	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation altering degron motif	0.6556
p.V702F	DO228940	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.S3440I	DO228974	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation altering degron motif	0.7341
p.A3622S	DO228974	LICA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.2778
p.G2299V	DO228971	LICA	ICGC	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation rewiring degron network	0.0833
p.S2521I	DO229019	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.1111
p.A2942S	DO229028	LICA	ICGC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation altering degron motif	0.6477
p.G3433V	DO229037	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	3437:3441	Mutation rewiring degron network	0.2222
p.A2522S	DO229041	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.1389
p.S2519I	DO229041	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.0556
p.S1541I	DO229045	LICA	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation altering degron motif	0.623
p.M3507V	DO50875	LICA	ICGC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.0556
p.T1540A	DO45195	LIRI	ICGC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation altering degron motif	0.6028
p.T3510I	DO220877	MELA	ICGC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.1389
p.S3524P	DO220903	MELA	ICGC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.1944
p.V3638I	DO49460	PACA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.1667
p.V3638I	SIDM00845	Burkitt's Lymphoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.1667
p.V3638I	SIDM01519	Head and Neck Carcinoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.1667
p.P4040S	DO232224	PBCA	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.1389
p.S4034T	DO229234	THCA	ICGC	VSSST	DEG_SPOP_SBC_1	4029:4033	Mutation rewiring degron network	0.3056
p.A2933V	SIDM02026	Colorectal Carcinoma	GDSC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.1111
p.R700S	SIDM01265	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.R700S	ACH-000763	Myeloma	CCLE	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.R700S	MM1S	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.V2937I	SIDM00845	Burkitt's Lymphoma	GDSC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.2222
p.V2959I	SIDM00845	Burkitt's Lymphoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5965
p.V2959I	SIDM01519	Head and Neck Carcinoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5965
p.V2959I	ACH-000786	Lymphoma	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5965
p.V2959I	ACH-000992	Head and Neck Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5965
p.E3642D	SIDM00845	Burkitt's Lymphoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	3624:3632	Mutation rewiring degron network	0.0556
p.S1544R	SIDM00600	Thyroid Gland Carcinoma	GDSC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2778
p.S1544R	ACH-001528	Thyroid Cancer	CCLE	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2778
p.S1544R	IHH-4	thyroid	COSMIC	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.2778
p.R700I	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.R700I	ACH-000718	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.R700I	NCI-H2291	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.T2950P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.T2950P	ACH-001669	Leukemia	CCLE	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950P	ACH-001669	Leukemia	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.T2950P	ACH-002238	Leukemia	CCLE	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950P	ACH-002238	Leukemia	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.T2950P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222
p.V2959F	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5957
p.V2959F	ACH-001233	Lung Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5957
p.V2959F	VMRC-LCD	lung	COSMIC	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation altering degron motif	0.5957
p.P705L	SIDM00516	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P705L	ACH-002166	Skin Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P705L	MZ7-mel	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.N2306S	SIDM00537	Colorectal Carcinoma	GDSC	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation rewiring degron network	0.2778
p.N2306S	ACH-000982	Colon/Colorectal Cancer	CCLE	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation rewiring degron network	0.2778
p.N2306S	ACH-001345	Colon/Colorectal Cancer	CCLE	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation rewiring degron network	0.2778
p.N2306S	GP5d	large intestine	COSMIC	LEGTPQRS	DEG_SCF_FBW7_1	2308:2315	Mutation rewiring degron network	0.2778
p.Q3527H	SIDM00168	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.1111
p.Q3527H	ACH-000549	Head and Neck Cancer	CCLE	DYR	CBL_MET	3517:3519	Mutation rewiring degron network	0.1111
p.L2544V	SIDM01323	Oral Cavity Carcinoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.0833
p.L2544V	ACH-000732	Head and Neck Cancer	CCLE	VCTPQNS	DEG_SCF_FBW7_1	2529:2535	Mutation rewiring degron network	0.0833
p.S703F	SIDM01587	Bladder Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2778
p.S703F	ACH-000753	Bladder Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2778
p.S2321I	ACH-000887	Brain Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	2319:2323	Mutation altering degron motif	0.8453
p.S1528F	ACH-001568	Skin Cancer	CCLE	LDTPTSE	DEG_SCF_FBW7_2	1536:1542	Mutation rewiring degron network	0.1111
p.T2950S	ACH-001623	Brain Cancer	CCLE	IATPLPS	DEG_SCF_FBW7_1	2941:2947	Mutation rewiring degron network	0.25
p.T2950S	ACH-001623	Brain Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	2954:2961	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1109

UniProt ID: Q2LD37

Entrez ID: 84162

Protein name: Transmembrane protein KIAA1109 (Fragile site-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1109 in