DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: LIG_APCC_ABBA_1

Location: 2680:2685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8892

ASA_SCORE: 83.3333

COIL: 0.7485

CONS_SCORE: 0.3536

DSS_SCORE: 0.5153

HELIX: 0.0595

FCONS_SCORE: 1.0315

RIG_SCORE: 0.7498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2692L	TCGA-33-6738	LUSC	TCGA	MTIHMD	LIG_APCC_ABBA_1	0.1389
p.V2692L	DO26516	LUSC	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.1389
p.G2672C	TCGA-A5-A0G2	UCEC	TCGA	MTIHMD	LIG_APCC_ABBA_1	0.1111
p.G2672C	DO41235	UCEC	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.1111
p.S2693L	TCGA-EE-A182	SKCM	TCGA	MTIHMD	LIG_APCC_ABBA_1	0.1111
p.S2693L	DO37814	SKCM	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.1111
p.M2680I	DO48442	BLCA	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.6507
p.M2680I	DO229026	LICA	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.6507
p.R2670S	DO50392	ESAD	ICGC	MTIHMD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	LIG_APCC_ABBA_1	2680:2685	MTIHMD	APC,CDC20,FZR1	0.8892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons