DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SCF_FBW7_1

Location: 2954:2961

E3 ligase: FBXW7

DEGRON score: 0.9447

ASA_SCORE: 97.3125

COIL: 0.9144

CONS_SCORE: 0.3945

DSS_SCORE: 0.6589

HELIX: 0.0574

FCONS_SCORE: 1.0481

RIG_SCORE: 0.6841

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2959D	TCGA-AR-A24S	BRCA	TCGA	VNQTPVET	DEG_SCF_FBW7_1	0.6674
p.V2959D	DO1414	BRCA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.6674
p.V2959I	SIDM00845	Burkitt's Lymphoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	0.5965
p.V2959I	SIDM01519	Head and Neck Carcinoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	0.5965
p.V2959I	ACH-000786	Lymphoma	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.5965
p.V2959I	ACH-000992	Head and Neck Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.5965
p.V2959F	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VNQTPVET	DEG_SCF_FBW7_1	0.5957
p.V2959F	ACH-001233	Lung Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.5957
p.V2959F	VMRC-LCD	lung	COSMIC	VNQTPVET	DEG_SCF_FBW7_1	0.5957
p.T2950N	TCGA-BR-8382	STAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950N	TCGA-DM-A1HB	COAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950N	DO47925	STAD	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950P	ACH-001669	Leukemia	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950P	ACH-002238	Leukemia	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.T2950S	ACH-001623	Brain Cancer	CCLE	VNQTPVET	DEG_SCF_FBW7_1	0.2222
p.Q2966K	TCGA-EE-A20C	SKCM	TCGA	VNQTPVET	DEG_SCF_FBW7_1	0.1944
p.Q2966K	DO222775	MELA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.1944
p.Q2966K	DO47665	SKCM	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.1944
p.P2968S	TCGA-99-8025	LUAD	TCGA	VNQTPVET	DEG_SCF_FBW7_1	0.1389
p.P2968S	DO24255	LUAD	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.1389
p.G2970D	DO1118	BRCA	ICGC	VNQTPVET	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_SCF_FBW7_1	2954:2961	VNQTPVET	FBXW7	0.9447	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons