DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SCF_FBW7_1

Location: 2529:2535

E3 ligase: FBXW7

DEGRON score: 0.5341

ASA_SCORE: 79.2286

COIL: 0.8384

CONS_SCORE: 0.3309

DSS_SCORE: 0.1656

HELIX: 0.0577

FCONS_SCORE: 0.8869

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2536I	TCGA-AX-A06F	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.3056
p.T2536I	DO41752	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.3056
p.A2538T	TCGA-B5-A3FA	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.25
p.A2538T	DO52402	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.25
p.S2537G	TCGA-BG-A0LX	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.2778
p.S2537G	DO41919	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.2778
p.V2529M	TCGA-DB-5279	LGG	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	SIDM00266	Ewing's Sarcoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	SIDM00056	Thyroid Gland Carcinoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	SIDM01316	Ewing's Sarcoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	ES1	bone	COSMIC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.V2529M	K5	thyroid	COSMIC	VCTPQNS	DEG_SCF_FBW7_1	0.6097
p.S2528F	TCGA-EE-A3AB	SKCM	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.3056
p.S2528F	DO222670	MELA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.3056
p.S2528F	DO38057	SKCM	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.3056
p.S2537N	TCGA-FI-A2D0	UCEC	TCGA	VCTPQNS	DEG_SCF_FBW7_1	0.2778
p.S2537N	DO43891	UCEC	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.2778
p.S2521I	DO229019	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.1111
p.A2522S	DO229041	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.1389
p.S2519I	DO229041	LICA	ICGC	VCTPQNS	DEG_SCF_FBW7_1	0.0556
p.L2544V	SIDM01323	Oral Cavity Carcinoma	GDSC	VCTPQNS	DEG_SCF_FBW7_1	0.0833
p.L2544V	ACH-000732	Head and Neck Cancer	CCLE	VCTPQNS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_SCF_FBW7_1	2529:2535	VCTPQNS	FBXW7	0.5341	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons