DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SCF_FBW7_2

Location: 1536:1542

E3 ligase: FBXW7

DEGRON score: 0.9534

ASA_SCORE: 79.5429

COIL: 0.8811

CONS_SCORE: 0.3729

DSS_SCORE: 0.5477

HELIX: 0.0774

FCONS_SCORE: 1.0278

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1542K	TCGA-4Z-AA7W	BLCA	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.7022
p.E1542K	DO218984	BLCA	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.7022
p.S1526C	TCGA-AG-A01J	READ	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.0556
p.S1526C	DO36385	READ	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.0556
p.R1532C	TCGA-CR-6481	HNSC	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532C	TCGA-D3-A51T	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532C	TCGA-EE-A3AG	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532C	DO14990	HNSC	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532C	DO37471	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532C	DO47389	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.S1529L	TCGA-D3-A8GI	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.1389
p.S1529L	DO50284	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.1389
p.R1532H	TCGA-FR-A728	SKCM	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.R1532H	DO48550	SKCM	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.2222
p.S1552Y	TCGA-VQ-A8P2	STAD	TCGA	LDTPTSE	DEG_SCF_FBW7_2	0.0556
p.S1552Y	DO51761	STAD	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.0556
p.S1541I	DO229045	LICA	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.623
p.T1540A	DO45195	LIRI	ICGC	LDTPTSE	DEG_SCF_FBW7_2	0.6028
p.S1544R	SIDM00600	Thyroid Gland Carcinoma	GDSC	LDTPTSE	DEG_SCF_FBW7_2	0.2778
p.S1544R	ACH-001528	Thyroid Cancer	CCLE	LDTPTSE	DEG_SCF_FBW7_2	0.2778
p.S1544R	IHH-4	thyroid	COSMIC	LDTPTSE	DEG_SCF_FBW7_2	0.2778
p.S1528F	ACH-001568	Skin Cancer	CCLE	LDTPTSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_SCF_FBW7_2	1536:1542	LDTPTSE	FBXW7	0.9534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons