DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SCF_FBW7_1

Location: 2308:2315

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 85.0125

COIL: 0.8394

CONS_SCORE: 0.3613

DSS_SCORE: 0.489

HELIX: 0.1181

FCONS_SCORE: 1.0767

RIG_SCORE: 0.6794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2315N	TCGA-BR-6452	STAD	TCGA	LEGTPQRS	DEG_SCF_FBW7_1	0.7069
p.S2315N	DO38404	STAD	ICGC	LEGTPQRS	DEG_SCF_FBW7_1	0.7069
p.G2299V	DO228971	LICA	ICGC	LEGTPQRS	DEG_SCF_FBW7_1	0.0833
p.N2306S	SIDM00537	Colorectal Carcinoma	GDSC	LEGTPQRS	DEG_SCF_FBW7_1	0.2778
p.N2306S	ACH-000982	Colon/Colorectal Cancer	CCLE	LEGTPQRS	DEG_SCF_FBW7_1	0.2778
p.N2306S	ACH-001345	Colon/Colorectal Cancer	CCLE	LEGTPQRS	DEG_SCF_FBW7_1	0.2778
p.N2306S	GP5d	large_intestine	COSMIC	LEGTPQRS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_SCF_FBW7_1	2308:2315	LEGTPQRS	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons