DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SCF_FBW7_1

Location: 2941:2947

E3 ligase: FBXW7

DEGRON score: 0.9759

ASA_SCORE: 90.0286

COIL: 0.9289

CONS_SCORE: 0.3634

DSS_SCORE: 0.7061

HELIX: 0.0447

FCONS_SCORE: 1.0184

RIG_SCORE: 0.638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2947Y	TCGA-B5-A1MR	UCEC	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.712
p.S2947Y	DO41758	UCEC	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.712
p.T2943A	TCGA-BR-4361	STAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.7139
p.T2943A	DO38887	STAD	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.7139
p.T2950N	TCGA-BR-8382	STAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950N	TCGA-DM-A1HB	COAD	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950N	DO47925	STAD	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.25
p.S2947F	TCGA-EB-A44O	SKCM	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.7982
p.S2947F	DO47272	SKCM	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.7982
p.P2934T	TCGA-XF-A9SZ	BLCA	TCGA	IATPLPS	DEG_SCF_FBW7_1	0.1389
p.P2934T	DO51919	BLCA	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.1389
p.A2942S	DO229028	LICA	ICGC	IATPLPS	DEG_SCF_FBW7_1	0.6477
p.A2933V	SIDM02026	Colorectal Carcinoma	GDSC	IATPLPS	DEG_SCF_FBW7_1	0.1111
p.V2937I	SIDM00845	Burkitt's Lymphoma	GDSC	IATPLPS	DEG_SCF_FBW7_1	0.2222
p.T2950P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950P	ACH-001669	Leukemia	CCLE	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950P	ACH-002238	Leukemia	CCLE	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	IATPLPS	DEG_SCF_FBW7_1	0.25
p.T2950S	ACH-001623	Brain Cancer	CCLE	IATPLPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_SCF_FBW7_1	2941:2947	IATPLPS	FBXW7	0.9759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons