DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_SPOP_SBC_1

Location: 705:709

E3 ligase: SPOP

DEGRON score: 0.8945

ASA_SCORE: 77.98

COIL: 0.9266

CONS_SCORE: 0.3176

DSS_SCORE: 0.716

HELIX: 0.0504

FCONS_SCORE: 0.8336

RIG_SCORE: 0.5087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R710H	TCGA-AA-3510	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	0.3056
p.R710H	DO7783	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	0.3056
p.R710C	TCGA-AX-A1CE	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	0.3056
p.R710C	DO42280	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	0.3056
p.V701L	DO1123	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	0.2222
p.V702F	DO228940	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	0.25
p.R700S	SIDM01265	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	0.1944
p.R700S	ACH-000763	Myeloma	CCLE	PSTSS	DEG_SPOP_SBC_1	0.1944
p.R700S	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	0.1944
p.R700I	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	0.1944
p.R700I	ACH-000718	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	0.1944
p.R700I	NCI-H2291	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	0.1944
p.P705L	SIDM00516	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	0.7582
p.P705L	ACH-002166	Skin Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	0.7582
p.P705L	MZ7-mel	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	0.7582
p.S703F	SIDM01587	Bladder Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	0.2778
p.S703F	ACH-000753	Bladder Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JE40	Protein PAT1 homolog 2	DEG_SPOP_SBC_1	116:120	PSTSS	SPOP	0.813	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	705:709	PSTSS	SPOP	0.9214	More...
O75167	Phosphatase and actin regulator 2	DEG_SPOP_SBC_1	238:242	PSTSS	SPOP	0.996	More...
O94888	UBX domain-containing protein 7	DEG_SPOP_SBC_1	59:63	PSTSS	SPOP	0.9924	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	272:276	PSTSS	SPOP	0.9991	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	75:79	PSTSS	SPOP	0.9983	More...
P35226	Polycomb complex protein BMI-1	DEG_SPOP_SBC_1	266:270	PSTSS	SPOP	0.9626	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1730:1734	PSTSS	SPOP	0.9838	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	150:154	PSTSS	SPOP	0.9991	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	1080:1084	PSTSS	SPOP	0.9984	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1572:1576	PSTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1945:1949	PSTSS	SPOP	0.9955	More...
P98161	Polycystin-1	DEG_SPOP_SBC_1	4187:4191	PSTSS	SPOP	0.9955	More...
Q00987	E3 ubiquitin-protein ligase Mdm2	DEG_SPOP_SBC_1	156:160	PSTSS	SPOP	0.9632	More...
Q00987	E3 ubiquitin-protein ligase Mdm2	DEG_SPOP_SBC_1	397:401	PSTSS	SPOP	0.9972	More...
Q12857	Nuclear factor 1 A-type	DEG_SPOP_SBC_1	267:271	PSTSS	SPOP	0.9935	More...
Q13620	Cullin-4B	DEG_SPOP_SBC_1	96:100	PSTSS	SPOP	0.9962	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	648:652	PSTSS	SPOP	0.998	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	753:757	PSTSS	SPOP	0.997	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	705:709	PSTSS	SPOP	0.8945	More...
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_SPOP_SBC_1	2774:2778	PSTSS	SPOP	0.6499	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	411:415	PSTSS	SPOP	0.8661	More...
Q5JTV8	Torsin-1A-interacting protein 1	DEG_SPOP_SBC_1	316:320	PSTSS	SPOP	0.655	More...
Q5T5C0	Syntaxin-binding protein 5	DEG_SPOP_SBC_1	583:587	PSTSS	SPOP	0.7149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3974:3978	PSTSS	SPOP	0.8169	More...
Q6ULP2	Aftiphilin	DEG_SPOP_SBC_1	926:930	PSTSS	SPOP	0.8606	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2191:2195	PSTSS	SPOP	0.9386	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2949:2953	PSTSS	SPOP	0.8713	More...
Q86YA3	Protein ZGRF1	DEG_SPOP_SBC_1	729:733	PSTSS	SPOP	0.9383	More...
Q8IV36	Protein HID1	DEG_SPOP_SBC_1	669:673	PSTSS	SPOP	0.9682	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	51:55	PSTSS	SPOP	0.7339	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1521:1525	PSTSS	SPOP	0.9997	More...
Q92783	Signal transducing adapter molecule 1	DEG_SPOP_SBC_1	199:203	PSTSS	SPOP	0.9995	More...
Q969T4	Ubiquitin-conjugating enzyme E2 E3	DEG_SPOP_SBC_1	13:17	PSTSS	SPOP	0.9873	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	910:914	PSTSS	SPOP	0.8977	More...
Q96JG8	Melanoma-associated antigen D4	DEG_SPOP_SBC_1	716:720	PSTSS	SPOP	0.6971	More...
Q9BQE4	Selenoprotein S	DEG_SPOP_SBC_1	143:147	PSTSS	SPOP	0.9603	More...
Q9BTA9	WW domain-containing adapter protein with coiled-coil	DEG_SPOP_SBC_1	322:326	PSTSS	SPOP	0.9374	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	545:549	PSTSS	SPOP	0.8099	More...
Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	DEG_SPOP_SBC_1	69:73	PSTSS	SPOP	0.9923	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_SPOP_SBC_1	361:365	PSTSS	SPOP	0.9768	More...
Q9NQB0	Transcription factor 7-like 2	DEG_SPOP_SBC_1	592:596	PSTSS	SPOP	0.9981	More...
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	DEG_SPOP_SBC_1	28:32	PSTSS	SPOP	0.9795	More...
Q9UKA4	A-kinase anchor protein 11	DEG_SPOP_SBC_1	248:252	PSTSS	SPOP	0.9869	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1550:1554	PSTSS	SPOP	0.9951	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	737:741	PSTSS	SPOP	0.9725	More...
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	DEG_SPOP_SBC_1	660:664	PSTSS	SPOP	0.9612	More...
Q9UQC2	GRB2-associated-binding protein 2	DEG_SPOP_SBC_1	630:634	PSTSS	SPOP	0.9605	More...
Q9UQQ2	SH2B adapter protein 3	DEG_SPOP_SBC_1	325:329	PSTSS	SPOP	0.9519	More...
Q9Y4B5	Microtubule cross-linking factor 1	DEG_SPOP_SBC_1	1408:1412	PSTSS	SPOP	0.9928	More...
A6NNA5	Dorsal root ganglia homeobox protein	DEG_SPOP_SBC_1	228:232	PSTSS	SPOP	0.9943	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	405:409	PSTSS	SPOP	0.9032	More...
Q68CL5	Tubulin polyglutamylase complex subunit 2	DEG_SPOP_SBC_1	282:286	PSTSS	SPOP	0.831	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	42:46	PSTSS	SPOP	0.9388	More...
Q96P50	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	384:388	PSTSS	SPOP	0.8937	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	1256:1260	PSTSS	SPOP	0.9871	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	54:58	PSTSS	SPOP	0.882	More...
P0C671	Protein BNIP5	DEG_SPOP_SBC_1	484:488	PSTSS	SPOP	0.9868	More...
Q8N9B4	Ankyrin repeat domain-containing protein 42	DEG_SPOP_SBC_1	9:13	PSTSS	SPOP	0.7987	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	218:222	PSTSS	SPOP	0.5489	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTSS

Degron related mutations and impact score

Drug responses associated with KIAA1109 mutations

All proteins holding degron of PSTSS