DegronMD - O94888(UBXN7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R78C	TCGA-55-8506	LUAD	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.R78C	TCGA-AP-A1E0	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.A56T	TCGA-AP-A051	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.A56T	DO42673	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.A56T	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.A56T	ACH-000563	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.A56T	EBC-1	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.E76D	TCGA-CD-A48A	STAD	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.E76D	DO47781	STAD	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.R78H	TCGA-CN-5360	HNSC	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.R78H	DO14662	HNSC	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.T73I	TCGA-EY-A1GU	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5966
p.T73I	DO41518	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5966
p.T73I	SIDM00217	Colorectal Carcinoma	GDSC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5966
p.T73I	ACH-000999	Colon/Colorectal Cancer	CCLE	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5966
p.T73I	SNU-1040	large intestine	COSMIC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5966
p.V69A	TCGA-FI-A2D5	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6936
p.V69A	DO41331	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6936
p.R67T	DO44121	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.R67T	DO44121	BRCA	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.T61N	DO229015	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7055
p.P82T	DO222908	MELA	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1111
p.A64P	DO32819	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.A64P	DO32819	PACA	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1944
p.A64P	SIDM01136	Pancreatic Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.A64P	SIDM01136	Pancreatic Carcinoma	GDSC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1944
p.A64P	ACH-000417	Pancreatic Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.A64P	ACH-000417	Pancreatic Cancer	CCLE	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1944
p.A64P	PANC-08-13	pancreas	COSMIC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.A64P	PANC-08-13	pancreas	COSMIC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1944
p.I68M	DO42977	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944
p.I68M	DO42977	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.3056
p.G53E	SIDM00660	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1667
p.G53E	ACH-000985	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1667
p.G53E	LS-411N	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1667
p.Y54H	CCK-81	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944

Kaplan plot for UBXN7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBXN7

UniProt ID: O94888

Entrez ID: 26043

Protein name: UBX domain-containing protein 7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBXN7 in