DegronMD

Uniprot ID: O94888

Source protein: UBX domain-containing protein 7

Source gene: UBXN7

Class: LIG_APCC_ABBA_1

Location: 69:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.927

ASA_SCORE: 101.5667

COIL: 0.8798

CONS_SCORE: 0.3145

DSS_SCORE: 0.6127

HELIX: 0.1127

FCONS_SCORE: 0.7422

RIG_SCORE: 0.6786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R78C	TCGA-55-8506	LUAD	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.2222
p.R78C	TCGA-AP-A1E0	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.2222
p.E76D	TCGA-CD-A48A	STAD	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.2778
p.E76D	DO47781	STAD	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.2778
p.R78H	TCGA-CN-5360	HNSC	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.2222
p.R78H	DO14662	HNSC	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.2222
p.T73I	TCGA-EY-A1GU	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.5966
p.T73I	DO41518	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.5966
p.T73I	SIDM00217	Colorectal Carcinoma	GDSC	VRPHTE	LIG_APCC_ABBA_1	0.5966
p.T73I	ACH-000999	Colon/Colorectal Cancer	CCLE	VRPHTE	LIG_APCC_ABBA_1	0.5966
p.T73I	SNU-1040	large_intestine	COSMIC	VRPHTE	LIG_APCC_ABBA_1	0.5966
p.V69A	TCGA-FI-A2D5	UCEC	TCGA	VRPHTE	LIG_APCC_ABBA_1	0.6936
p.V69A	DO41331	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.6936
p.R67T	DO44121	BRCA	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.2778
p.P82T	DO222908	MELA	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.1111
p.A64P	DO32819	PACA	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.1944
p.A64P	SIDM01136	Pancreatic Carcinoma	GDSC	VRPHTE	LIG_APCC_ABBA_1	0.1944
p.A64P	ACH-000417	Pancreatic Cancer	CCLE	VRPHTE	LIG_APCC_ABBA_1	0.1944
p.A64P	PANC-08-13	pancreas	COSMIC	VRPHTE	LIG_APCC_ABBA_1	0.1944
p.I68M	DO42977	UCEC	ICGC	VRPHTE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94888	UBX domain-containing protein 7	LIG_APCC_ABBA_1	69:74	VRPHTE	APC,CDC20,FZR1	0.927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons