DegronMD - Q9UQC2(GAB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T331N	TCGA-24-1551	OV	TCGA	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation blocking phosphorylation signal	0.5
p.P621Q	TCGA-55-7910	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.R380I	TCGA-5M-AAT4	COAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.1111
p.L462M	TCGA-75-6214	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.D450N	TCGA-77-7141	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.T340S	TCGA-AP-A051	UCEC	TCGA	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.N397S	TCGA-AZ-6601	COAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.3056
p.R389H	TCGA-B5-A3FA	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.8244
p.N390S	TCGA-BR-8487	STAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.5958
p.A394V	TCGA-D1-A17A	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.5825
p.S405F	TCGA-D3-A3MR	SKCM	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation blocking phosphorylation signal	0.5278
p.R402Q	TCGA-DF-A2KN	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.1667
p.A384V	TCGA-EO-A22U	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.2222
p.D450Y	TCGA-FR-A3YO	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.A338T	TCGA-Q1-A5R1	CESC	TCGA	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.25
p.V382F	TCGA-ZJ-AAXA	CESC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.1667
p.V460M	DO51926	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.7208
p.T456K	DO49806	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.R462Q	DO49795	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.E622Q	DO2401	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation blocking phosphorylation signal	0.5556
p.K634N	DO5808	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.6918
p.K634N	DO47867	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.6918
p.V344F	DO219752	CESC	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7068
p.P464L	DO48976	CESC	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.25
p.R342I	DO223702	COAD	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.8102
p.G382R	DO230332	COCA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.1667
p.A345T	DO233156	GACA	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7139
p.E379Q	DO233190	GACA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.0833
p.E379Q	AU565	breast	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.0833
p.T624I	DO233652	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.P397Q	DO229019	LICA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.3056
p.T457N	DO229041	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.7055
p.L451I	DO229008	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1667
p.R627W	DO49657	LIHC	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.R627W	C-33-A	cervix	COSMIC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.M400I	DO228326	MALY	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.2222
p.V392G	DO232846	NACA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.7532
p.S465R	DO29228	OV	ICGC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2222
p.D406E	DO49756	PRAD	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.0556
p.V626M	DO48632	PRAD	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.N352S	DO47867	STAD	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1944
p.R627Q	DO229224	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.S630L	DO41752	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.7667
p.R351H	DO52402	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.A381V	DO42600	UCEC	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation rewiring degron network	0.1389
p.A356V	DO43875	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0833
p.A346V	DO43755	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.6936
p.L638M	DO42472	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.T340K	SIDM00386	Ewing's Sarcoma	GDSC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.T340K	ACH-000391	Bone Cancer	CCLE	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.T340K	MHH-ES-1	bone	COSMIC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.P344L	SIDM01180	Hepatocellular Carcinoma	GDSC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7582
p.P344L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7582
p.R389C	SIDM00807	Bladder Carcinoma	GDSC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.8301
p.R389C	ACH-000905	Bladder Cancer	CCLE	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.8301
p.R389C	5637	urinary tract	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.8301
p.M465I	SIDM01077	Prostate Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2222
p.M465I	ACH-000115	Prostate Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2222
p.M465I	VCaP	prostate	COSMIC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2222
p.T343N	ACH-000350	Colon/Colorectal Cancer	CCLE	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7055
p.P459H	SNU-175	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.7694
p.T391P	RL95-2	endometrium	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.7031
p.T353P	RL95-2	endometrium	COSMIC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1667
p.R404L	BL-41	haematopoietic and lymphoid tissue	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation blocking phosphorylation signal	0.5556
p.R404Q	NCI-H2135	lung	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation blocking phosphorylation signal	0.5556
p.R404Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation blocking phosphorylation signal	0.5556
p.G393S	5637	urinary tract	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	388:396	Mutation altering degron motif	0.6993
p.R351C	5637	urinary tract	COSMIC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.V341A	PANC-03-27	pancreas	COSMIC	VATPGDS	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAB2

UniProt ID: Q9UQC2

Entrez ID: 9846

Protein name: GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAB2 in