DegronMD

Uniprot ID: Q9UQC2

Source protein: GRB2-associated-binding protein 2

Source gene: GAB2

Class: DEG_APCC_DBOX_1

Location: 388:396

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9793

ASA_SCORE: 84.0444

COIL: 0.8324

CONS_SCORE: 0.3668

DSS_SCORE: 0.6082

HELIX: 0.1022

FCONS_SCORE: 1.1512

RIG_SCORE: 0.6887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R380I	TCGA-5M-AAT4	COAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.1111
p.N397S	TCGA-AZ-6601	COAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.3056
p.R389H	TCGA-B5-A3FA	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.8244
p.N390S	TCGA-BR-8487	STAD	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.5958
p.A394V	TCGA-D1-A17A	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.5825
p.S405F	TCGA-D3-A3MR	SKCM	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.5278
p.R402Q	TCGA-DF-A2KN	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.1667
p.A384V	TCGA-EO-A22U	UCEC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.2222
p.V382F	TCGA-ZJ-AAXA	CESC	TCGA	RRNTLPAMD	DEG_APCC_DBOX_1	0.1667
p.G382R	DO230332	COCA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.1667
p.E379Q	DO233190	GACA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.0833
p.E379Q	AU565	breast	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.0833
p.P397Q	DO229019	LICA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.3056
p.M400I	DO228326	MALY	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.2222
p.V392G	DO232846	NACA	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.7532
p.D406E	DO49756	PRAD	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.0556
p.A381V	DO42600	UCEC	ICGC	RRNTLPAMD	DEG_APCC_DBOX_1	0.1389
p.R389C	SIDM00807	Bladder Carcinoma	GDSC	RRNTLPAMD	DEG_APCC_DBOX_1	0.8301
p.R389C	ACH-000905	Bladder Cancer	CCLE	RRNTLPAMD	DEG_APCC_DBOX_1	0.8301
p.R389C	5637	urinary_tract	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.8301
p.T391P	RL95-2	endometrium	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.7031
p.R404L	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.5556
p.R404Q	NCI-H2135	lung	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.5556
p.R404Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.5556
p.G393S	5637	urinary_tract	COSMIC	RRNTLPAMD	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQC2	GRB2-associated-binding protein 2	DEG_APCC_DBOX_1	388:396	RRNTLPAMD	APC,CDC20,FZR1	0.9793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRNTLPAMD

Degron related mutations and impact score

Drug responses associated with GAB2 mutations

All proteins holding degron of RRNTLPAMD