DegronMD

Uniprot ID: Q9UQC2

Source protein: GRB2-associated-binding protein 2

Source gene: GAB2

Class: DEG_SCF_FBW7_1

Location: 341:347

E3 ligase: FBXW7

DEGRON score: 0.9907

ASA_SCORE: 76.9857

COIL: 0.9139

CONS_SCORE: 0.2846

DSS_SCORE: 0.6895

HELIX: 0.0644

FCONS_SCORE: 0.7979

RIG_SCORE: 0.6499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T331N	TCGA-24-1551	OV	TCGA	VATPGDS	DEG_SCF_FBW7_1	0.5
p.T340S	TCGA-AP-A051	UCEC	TCGA	VATPGDS	DEG_SCF_FBW7_1	0.3056
p.A338T	TCGA-Q1-A5R1	CESC	TCGA	VATPGDS	DEG_SCF_FBW7_1	0.25
p.V344F	DO219752	CESC	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.7068
p.R342I	DO223702	COAD	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.8102
p.A345T	DO233156	GACA	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.7139
p.N352S	DO47867	STAD	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.1944
p.R351H	DO52402	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.2222
p.A356V	DO43875	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.0833
p.A346V	DO43755	UCEC	ICGC	VATPGDS	DEG_SCF_FBW7_1	0.6936
p.T340K	SIDM00386	Ewing's Sarcoma	GDSC	VATPGDS	DEG_SCF_FBW7_1	0.3056
p.T340K	ACH-000391	Bone Cancer	CCLE	VATPGDS	DEG_SCF_FBW7_1	0.3056
p.T340K	MHH-ES-1	bone	COSMIC	VATPGDS	DEG_SCF_FBW7_1	0.3056
p.P344L	SIDM01180	Hepatocellular Carcinoma	GDSC	VATPGDS	DEG_SCF_FBW7_1	0.7582
p.P344L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VATPGDS	DEG_SCF_FBW7_1	0.7582
p.T343N	ACH-000350	Colon/Colorectal Cancer	CCLE	VATPGDS	DEG_SCF_FBW7_1	0.7055
p.T353P	RL95-2	endometrium	COSMIC	VATPGDS	DEG_SCF_FBW7_1	0.1667
p.R351C	5637	urinary_tract	COSMIC	VATPGDS	DEG_SCF_FBW7_1	0.2222
p.V341A	PANC-03-27	pancreas	COSMIC	VATPGDS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQC2	GRB2-associated-binding protein 2	DEG_SCF_FBW7_1	341:347	VATPGDS	FBXW7	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons