DegronMD - Q9NQB0(TCF7L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S578F	TCGA-06-5416	GBM	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1667
p.T205M	TCGA-2W-A8YY	CESC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7423
p.T205M	TCGA-E6-A1LX	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7423
p.T205M	DO223732	CESC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7423
p.T205M	DO41020	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7423
p.F211S	TCGA-49-AAR4	LUAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1667
p.F211S	DO218920	LUAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1667
p.A587S	TCGA-55-1592	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7588
p.Q574H	TCGA-90-A59Q	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.T212M	TCGA-91-8497	LUAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation blocking phosphorylation signal	0.5833
p.T212M	DO45325	LUAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation blocking phosphorylation signal	0.5833
p.V191M	TCGA-A5-A0G2	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1111
p.V191M	DO41235	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1111
p.T598N	TCGA-AA-A022	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.T598N	TCGA-AA-A022	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.S207I	TCGA-AG-3726	READ	TCGA	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.S207I	DO36689	READ	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.Q574R	TCGA-CI-6619	READ	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.H583Y	TCGA-CK-4951	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.3056
p.H583Y	TCGA-CK-4951	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0833
p.P593L	TCGA-YG-AA3O	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7582
p.V201A	DO1653	BRCA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.6936
p.V201A	DO37703	SKCM	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.6936
p.H600Y	DO10582	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.R194K	DO7862	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1944
p.S595F	DO10880	GBM	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7982
p.I589V	DO49069	HNSC	ICGC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.3056
p.I589V	DO49069	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.V191L	DO229029	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1111
p.A604S	DO23556	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1111
p.Q591H	DO50103	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.Q591H	DO50103	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.Q591R	DO36495	READ	ICGC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.Q591R	DO36495	READ	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.S593P	DO231348	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.5641
p.S595L	SIDM01293	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7667
p.S579F	SIDM00007	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1944
p.S579F	MCC13	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1944
p.L200I	SIDM00945	Colorectal Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.6063
p.L200I	CL-34	large intestine	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.6063
p.I207V	SIDM00487	Colorectal Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.I207V	CCK-81	large intestine	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.S207C	SIDM00864	Cervical Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.S207C	DoTc2-4510	cervix	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.2778
p.A199S	ACH-000363	Myeloma	CCLE	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7588
p.A199S	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation altering degron motif	0.7588
p.P211L	ACH-000654	Lymphoma	CCLE	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1667
p.P211L	Raji	haematopoietic and lymphoid tissue	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	199:205	Mutation rewiring degron network	0.1667
p.S596F	MCC13	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7982
p.S584F	MCC13	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7982
p.A584V	ES6	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.5825

Kaplan plot for TCF7L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF7L2

UniProt ID: Q9NQB0

Entrez ID: 6934

Protein name: Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF7L2 in