DegronMD

Uniprot ID: Q9NQB0

Source protein: Transcription factor 7-like 2

Source gene: TCF7L2

Class: DEG_SCF_FBW7_1

Location: 199:205

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 57.7429

COIL: 0.8487

CONS_SCORE: 0.5264

DSS_SCORE: 0.53

HELIX: 0.0511

FCONS_SCORE: 1.0988

RIG_SCORE: 0.7114

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T205M	TCGA-2W-A8YY	CESC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.7423
p.T205M	TCGA-E6-A1LX	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.7423
p.T205M	DO223732	CESC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.7423
p.T205M	DO41020	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.7423
p.F211S	TCGA-49-AAR4	LUAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.F211S	DO218920	LUAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.T212M	TCGA-91-8497	LUAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.5833
p.T212M	DO45325	LUAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.5833
p.V191M	TCGA-A5-A0G2	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1111
p.V191M	DO41235	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1111
p.S207I	TCGA-AG-3726	READ	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.S207I	DO36689	READ	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.V201A	DO1653	BRCA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.6936
p.V201A	DO37703	SKCM	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.6936
p.R194K	DO7862	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1944
p.V191L	DO229029	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1111
p.L200I	SIDM00945	Colorectal Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.6063
p.L200I	CL-34	large_intestine	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.6063
p.I207V	SIDM00487	Colorectal Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.I207V	CCK-81	large_intestine	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.S207C	SIDM00864	Cervical Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.S207C	DoTc2-4510	cervix	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.A199S	ACH-000363	Myeloma	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.7588
p.A199S	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.7588
p.P211L	ACH-000654	Lymphoma	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.P211L	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS4	Transcription factor 7-like 1	DEG_SCF_FBW7_1	190:196	PLTPLIT	FBXW7	0.9764	More...
Q9NQB0	Transcription factor 7-like 2	DEG_SCF_FBW7_1	199:205	PLTPLIT	FBXW7	0.9982	More...
Q9UJU2	Lymphoid enhancer-binding factor 1	DEG_SCF_FBW7_1	153:159	PLTPLIT	FBXW7	0.9568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPLIT

Degron related mutations and impact score

Drug responses associated with TCF7L2 mutations

All proteins holding degron of PLTPLIT