DegronMD - Q9UJU2(LEF1)

GO - Biological processes (BP): anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell proliferation [GO:0042100]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-4 [GO:0071353]; chorio-allantoic fusion [GO:0060710]; dentate gyrus development [GO:0021542]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; face morphogenesis [GO:0060325]; forebrain neuroblast division [GO:0021873]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; histone H3 acetylation [GO:0043966]; histone H3-K56 acetylation [GO:0097043]; histone H4 acetylation [GO:0043967]; mammary gland development [GO:0030879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA binding [GO:0043392]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription, DNA-templated [GO:0045892]; neutrophil differentiation [GO:0030223]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; paraxial mesoderm formation [GO:0048341]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell cycle process [GO:0090068]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary palate development [GO:0062009]; sensory perception of taste [GO:0050909]; somitogenesis [GO:0001756]; sprouting angiogenesis [GO:0002040]; T cell receptor V(D)J recombination [GO:0033153]; T-helper 1 cell differentiation [GO:0045063]; tongue development [GO:0043586]; trachea gland development [GO:0061153] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P25S	TCGA-A5-A0G2	UCEC	TCGA	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6752
p.P25S	DO41235	UCEC	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6752
p.E163K	TCGA-AJ-A3EL	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.2222
p.D14G	TCGA-CK-6746	COAD	TCGA	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833
p.D14G	DO7938	COAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833
p.D14G	DO233935	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833
p.D14G	DO45299	LIRI	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833
p.V151A	TCGA-D7-8578	STAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.2778
p.A150V	TCGA-IB-7651	PAAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.25
p.A19V	TCGA-VQ-A91K	STAD	TCGA	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.A19V	DO51785	STAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.D24N	DO225353	BRCA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6932
p.D24N	DO233163	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6932
p.E29K	DO228324	BRCA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.E29K	SIDM00971	Breast Carcinoma	GDSC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.E29K	ACH-000828	Breast Cancer	CCLE	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.E29K	ZR-75-30	breast	COSMIC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.I167T	DO9002	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.1111
p.G153S	DO7962	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6993
p.G153S	DO219321	PRAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6993
p.G153S	DO40889	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6993
p.P38S	DO233823	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0556
p.R20K	DO219065	HNSC	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.25
p.G31A	DO220479	KICH	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.25
p.T169K	DO229029	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.0556
p.P152T	DO229022	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.3056
p.P29Q	DO229026	LICA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.G161D	DO22839	LIHC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation blocking phosphorylation signal	0.7222
p.G32C	DO218920	LUAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.E13D	DO23711	LUAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0556
p.P15S	DO220894	MELA	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1111
p.P23H	DO223286	UCEC	ICGC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.7694
p.F146L	DO43186	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.1389
p.P156S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6752
p.P156S	ACH-000924	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6752
p.P156S	NCI-H2172	lung	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation altering degron motif	0.6752
p.E35K	SIDM00516	Melanoma	GDSC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1389
p.E35K	ACH-002166	Skin Cancer	CCLE	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1389
p.E35K	MZ7-mel	skin	COSMIC	MIPFKD	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1389
p.G168R	ACH-000662	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.0833
p.H148R	TK10	kidney	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	153:159	Mutation rewiring degron network	0.1944

Kaplan plot for LEF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LEF1

UniProt ID: Q9UJU2

Entrez ID: 51176

Protein name: Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LEF1 in