DegronMD

Uniprot ID: Q9UJU2

Source protein: Lymphoid enhancer-binding factor 1

Source gene: LEF1

Class: LIG_APCC_ABBA_1

Location: 23:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8612

ASA_SCORE: 66.4833

COIL: 0.4733

CONS_SCORE: 0.4948

DSS_SCORE: 0.6878

HELIX: 0.056

FCONS_SCORE: 1.1223

RIG_SCORE: 0.7542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P25S	TCGA-A5-A0G2	UCEC	TCGA	MIPFKD	LIG_APCC_ABBA_1	0.6752
p.P25S	DO41235	UCEC	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.6752
p.D14G	TCGA-CK-6746	COAD	TCGA	MIPFKD	LIG_APCC_ABBA_1	0.0833
p.D14G	DO7938	COAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.0833
p.D14G	DO233935	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.0833
p.D14G	DO45299	LIRI	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.0833
p.A19V	TCGA-VQ-A91K	STAD	TCGA	MIPFKD	LIG_APCC_ABBA_1	0.2222
p.A19V	DO51785	STAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.2222
p.D24N	DO225353	BRCA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.6932
p.D24N	DO233163	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.6932
p.E29K	DO228324	BRCA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.3056
p.E29K	SIDM00971	Breast Carcinoma	GDSC	MIPFKD	LIG_APCC_ABBA_1	0.3056
p.E29K	ACH-000828	Breast Cancer	CCLE	MIPFKD	LIG_APCC_ABBA_1	0.3056
p.E29K	ZR-75-30	breast	COSMIC	MIPFKD	LIG_APCC_ABBA_1	0.3056
p.P38S	DO233823	GACA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.0556
p.R20K	DO219065	HNSC	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.25
p.G31A	DO220479	KICH	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.25
p.P29Q	DO229026	LICA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.3056
p.G32C	DO218920	LUAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.2222
p.E13D	DO23711	LUAD	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.0556
p.P15S	DO220894	MELA	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.1111
p.P23H	DO223286	UCEC	ICGC	MIPFKD	LIG_APCC_ABBA_1	0.7694
p.E35K	SIDM00516	Melanoma	GDSC	MIPFKD	LIG_APCC_ABBA_1	0.1389
p.E35K	ACH-002166	Skin Cancer	CCLE	MIPFKD	LIG_APCC_ABBA_1	0.1389
p.E35K	MZ7-mel	skin	COSMIC	MIPFKD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJU2	Lymphoid enhancer-binding factor 1	LIG_APCC_ABBA_1	23:28	MIPFKD	APC,CDC20,FZR1	0.8612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons