DegronMD

Uniprot ID: Q9UJU2

Source protein: Lymphoid enhancer-binding factor 1

Source gene: LEF1

Class: DEG_SCF_FBW7_1

Location: 153:159

E3 ligase: FBXW7

DEGRON score: 0.9568

ASA_SCORE: 41.1429

COIL: 0.7394

CONS_SCORE: 0.5272

DSS_SCORE: 0.4983

HELIX: 0.0354

FCONS_SCORE: 0.9702

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E163K	TCGA-AJ-A3EL	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.2222
p.V151A	TCGA-D7-8578	STAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.2778
p.A150V	TCGA-IB-7651	PAAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.25
p.I167T	DO9002	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1111
p.G153S	DO7962	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.6993
p.G153S	DO219321	PRAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.6993
p.G153S	DO40889	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.6993
p.T169K	DO229029	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.0556
p.P152T	DO229022	LICA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.3056
p.G161D	DO22839	LIHC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.7222
p.F146L	DO43186	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1389
p.P156S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.6752
p.P156S	ACH-000924	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.6752
p.P156S	NCI-H2172	lung	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.6752
p.G168R	ACH-000662	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.0833
p.H148R	TK10	kidney	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS4	Transcription factor 7-like 1	DEG_SCF_FBW7_1	190:196	PLTPLIT	FBXW7	0.9764	More...
Q9NQB0	Transcription factor 7-like 2	DEG_SCF_FBW7_1	199:205	PLTPLIT	FBXW7	0.9982	More...
Q9UJU2	Lymphoid enhancer-binding factor 1	DEG_SCF_FBW7_1	153:159	PLTPLIT	FBXW7	0.9568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons