DegronMD

Uniprot ID: Q9HCS4

Source protein: Transcription factor 7-like 1

Source gene: TCF7L1

Class: DEG_SCF_FBW7_1

Location: 190:196

E3 ligase: FBXW7

DEGRON score: 0.9764

ASA_SCORE: 60.9571

COIL: 0.8301

CONS_SCORE: 0.6193

DSS_SCORE: 0.5811

HELIX: 0.065

FCONS_SCORE: 1.0425

RIG_SCORE: 0.6907

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185L	TCGA-A6-2686	COAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1944
p.P185L	TCGA-B5-A3FC	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1944
p.P185L	DO7828	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1944
p.P185L	DO41871	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1944
p.P180S	TCGA-EE-A2MR	SKCM	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.0556
p.P180S	DO37819	SKCM	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.0556
p.F202L	TCGA-EK-A2R8	CESC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.F202L	DO51599	CESC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.H184Q	TCGA-EW-A1P4	BRCA	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.H184Q	DO5172	BRCA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.S206Y	TCGA-L5-A4OM	ESCA	TCGA	PLTPLIT	DEG_SCF_FBW7_1	0.0556
p.P190L	SIDM00761	Small Cell Lung Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.6471
p.P190L	ACH-000752	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.6471
p.P190L	NCI-H196	lung	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.6471
p.H184R	SIDM00151	Ovarian Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.H184R	ACH-000966	Ovarian Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	0.1667
p.H184R	IGROV-1	ovary	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS4	Transcription factor 7-like 1	DEG_SCF_FBW7_1	190:196	PLTPLIT	FBXW7	0.9764	More...
Q9NQB0	Transcription factor 7-like 2	DEG_SCF_FBW7_1	199:205	PLTPLIT	FBXW7	0.9982	More...
Q9UJU2	Lymphoid enhancer-binding factor 1	DEG_SCF_FBW7_1	153:159	PLTPLIT	FBXW7	0.9568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons