DegronMD - Q9HCS4(TCF7L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P185L	TCGA-A6-2686	COAD	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1944
p.P185L	TCGA-B5-A3FC	UCEC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1944
p.P185L	DO7828	COAD	ICGC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1944
p.P185L	DO41871	UCEC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1944
p.A521T	TCGA-D6-6515	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	528:532	Mutation rewiring degron network	0.1389
p.A521T	DO14206	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	528:532	Mutation rewiring degron network	0.1389
p.P180S	TCGA-EE-A2MR	SKCM	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.0556
p.P180S	DO37819	SKCM	ICGC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.0556
p.F202L	TCGA-EK-A2R8	CESC	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.F202L	DO51599	CESC	ICGC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.H184Q	TCGA-EW-A1P4	BRCA	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.H184Q	DO5172	BRCA	ICGC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.A527V	TCGA-IB-7651	PAAD	TCGA	AASSS	DEG_SPOP_SBC_1	528:532	Mutation rewiring degron network	0.3056
p.A527V	DO46657	PAAD	ICGC	AASSS	DEG_SPOP_SBC_1	528:532	Mutation rewiring degron network	0.3056
p.S206Y	TCGA-L5-A4OM	ESCA	TCGA	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.0556
p.G46C	DO229041	LICA	ICGC	LIPFQD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.P190L	SIDM00761	Small Cell Lung Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation altering degron motif	0.6471
p.P190L	ACH-000752	Lung Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation altering degron motif	0.6471
p.P190L	NCI-H196	lung	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation altering degron motif	0.6471
p.H184R	SIDM00151	Ovarian Carcinoma	GDSC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.H184R	ACH-000966	Ovarian Cancer	CCLE	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.H184R	IGROV-1	ovary	COSMIC	PLTPLIT	DEG_SCF_FBW7_1	190:196	Mutation rewiring degron network	0.1667
p.E48K	ACH-001289	Rhabdoid	CCLE	LIPFQD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.A34V	ACH-001991	Primary	CCLE	LIPFQD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.2222

Kaplan plot for TCF7L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF7L1

UniProt ID: Q9HCS4

Entrez ID: 83439

Protein name: Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF7L1 in