DegronMD

Uniprot ID: Q9HCS4

Source protein: Transcription factor 7-like 1

Source gene: TCF7L1

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8917

ASA_SCORE: 70.2667

COIL: 0.5238

CONS_SCORE: 0.6326

DSS_SCORE: 0.8608

HELIX: 0.0597

FCONS_SCORE: 1.0744

RIG_SCORE: 0.7378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G46C	DO229041	LICA	ICGC	LIPFQD	LIG_APCC_ABBA_1	0.25
p.E48K	ACH-001289	Rhabdoid	CCLE	LIPFQD	LIG_APCC_ABBA_1	0.1944
p.A34V	ACH-001991	Primary	CCLE	LIPFQD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS4	Transcription factor 7-like 1	LIG_APCC_ABBA_1	38:43	LIPFQD	APC,CDC20,FZR1	0.8917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons