DegronMD

Uniprot ID: Q9NQB0

Source protein: Transcription factor 7-like 2

Source gene: TCF7L2

Class: DEG_SPOP_SBC_1

Location: 592:596

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 74.76

COIL: 0.856

CONS_SCORE: 0.5341

DSS_SCORE: 0.5881

HELIX: 0.1024

FCONS_SCORE: 1.292

RIG_SCORE: 0.5346

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S595F	DO10880	GBM	ICGC	PSTSS	DEG_SPOP_SBC_1	0.7982
p.S596F	MCC13	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	0.7982
p.S595L	SIDM01293	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	0.7667
p.P593L	TCGA-YG-AA3O	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	0.7582
p.S593P	DO231348	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	0.5641
p.Q591H	DO50103	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	0.3056
p.Q591R	DO36495	READ	ICGC	PSTSS	DEG_SPOP_SBC_1	0.3056
p.T598N	TCGA-AA-A022	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	0.2778
p.I589V	DO49069	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	0.25
p.H600Y	DO10582	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	0.2222
p.A604S	DO23556	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	0.1111
p.H583Y	TCGA-CK-4951	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 12 of 12 entries

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Drug responses associated with TCF7L2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKA4	A-kinase anchor protein 11	DEG_SPOP_SBC_1	248:252	PSTSS	SPOP	0.9869	More...
Q6ULP2	Aftiphilin	DEG_SPOP_SBC_1	926:930	PSTSS	SPOP	0.8606	More...
Q8N9B4	Ankyrin repeat domain-containing protein 42	DEG_SPOP_SBC_1	9:13	PSTSS	SPOP	0.7987	More...
Q96P50	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	384:388	PSTSS	SPOP	0.8937	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1550:1554	PSTSS	SPOP	0.9951	More...
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_SPOP_SBC_1	2774:2778	PSTSS	SPOP	0.6499	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	705:709	PSTSS	SPOP	0.9214	More...
Q13620	Cullin-4B	DEG_SPOP_SBC_1	96:100	PSTSS	SPOP	0.9962	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	42:46	PSTSS	SPOP	0.9388	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	51:55	PSTSS	SPOP	0.7339	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	411:415	PSTSS	SPOP	0.8661	More...
A6NNA5	Dorsal root ganglia homeobox protein	DEG_SPOP_SBC_1	228:232	PSTSS	SPOP	0.9943	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	737:741	PSTSS	SPOP	0.9725	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2191:2195	PSTSS	SPOP	0.9386	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2949:2953	PSTSS	SPOP	0.8713	More...
Q00987	E3 ubiquitin-protein ligase Mdm2	DEG_SPOP_SBC_1	156:160	PSTSS	SPOP	0.9632	More...
Q00987	E3 ubiquitin-protein ligase Mdm2	DEG_SPOP_SBC_1	397:401	PSTSS	SPOP	0.9972	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	753:757	PSTSS	SPOP	0.997	More...
Q9UQC2	GRB2-associated-binding protein 2	DEG_SPOP_SBC_1	630:634	PSTSS	SPOP	0.9605	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	405:409	PSTSS	SPOP	0.9032	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	1256:1260	PSTSS	SPOP	0.9871	More...
Q96JG8	Melanoma-associated antigen D4	DEG_SPOP_SBC_1	716:720	PSTSS	SPOP	0.6971	More...
Q9Y4B5	Microtubule cross-linking factor 1	DEG_SPOP_SBC_1	1408:1412	PSTSS	SPOP	0.9928	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1730:1734	PSTSS	SPOP	0.9838	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3974:3978	PSTSS	SPOP	0.8169	More...

Showing 1 to 25 of 60 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTSS

Degron related mutations and impact score

Drug responses associated with TCF7L2 mutations

All proteins holding degron of PSTSS