DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
BNIP5
UniProt ID:
P0C671
Entrez ID:
389384
Protein name:
Protein BNIP5
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
BNIP5
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Show Degron:
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.A75T
SIDM00216
Colorectal Carcinoma
GDSC
PTPEET
DEG_SCF_FBW7_1
76:81
Mutation rewiring degron network
0.3056
p.T72I
SIDM01016
T-Lymphoblastic Leukemia
GDSC
PTPEET
DEG_SCF_FBW7_1
76:81
Mutation rewiring degron network
0.2222
p.T72I
SIDM01263
T-Lymphoblastic Leukemia
GDSC
PTPEET
DEG_SCF_FBW7_1
76:81
Mutation rewiring degron network
0.2222
p.D384N
SIDM00007
Other Solid Cancers
GDSC
VLPTPSES
DEG_SCF_FBW7_1
367:374
Mutation rewiring degron network
0.0556
p.S487C
SIDM00394
Cervical Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM00568
Gastric Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM00237
Non-Small Cell Lung Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM01061
Oral Cavity Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM01727
Chronic Myelogenous Leukemia
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM01690
Plasma Cell Myeloma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM01559
Melanoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.S487C
SIDM01774
Pancreatic Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation altering degron motif
0.7541
p.R498W
SIDM00375
Head and Neck Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation rewiring degron network
0.0556
p.R498W
SIDM01570
Ovarian Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
484:488
Mutation rewiring degron network
0.0556
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for BNIP5 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc