DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VLPTPSES
Uniprot ID:
P0C671
Source protein:
Protein BNIP5
Source gene:
BNIP5
Class:
DEG_SCF_FBW7_1
Location:
367:374
E3 ligase:
FBXW7
DEGRON score:
0.71
ASA_SCORE:
88.7875
COIL:
0.9478
CONS_SCORE:
0.6379
DSS_SCORE:
0.834
HELIX:
0.0298
FCONS_SCORE:
0.9786
RIG_SCORE:
0.5773
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D384N
SIDM00007
Other Solid Cancers
GDSC
VLPTPSES
DEG_SCF_FBW7_1
0.0556
Drug responses associated with BNIP5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLPTPSES
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C671
Protein BNIP5
DEG_SCF_FBW7_1
367:374
VLPTPSES
FBXW7
0.71
More...